The 145th Annual Meeting of the Pharmaceutical Society of Japan (Fukuoka)

Organizer: Imai Hirotaka (Grad. Sch. Pharmaceut. Sci., Kitasato Univ.), Atsushi Matsuzawa (Grad. Sch. Pharmaceut. Sci., Tohoku Univ.)

In 2012, a new form of cell death (ferroptosis) mediated by iron-dependent lipid oxidation was reported, and in the last 10 years, the regulatory factors have been revealed one after another, and it is currently the hottest area in cell death research. It has also been shown that ferroptosis is involved in the development of various diseases, not just those caused by ischemia-reperfusion, and the factors that carry it out are being developed as potential therapeutic agents, while ferroptosis inhibitors are being developed as therapeutic agents, and ferroptosis inducers are being developed as new anticancer drugs. In Japan, new regulatory factors and mechanisms are being revealed in the study of lipid oxidation-dependent cell death. In this symposium, we will discuss the regulation of lysosomal function in ferroptosis caused by lipid oxidation, the relationship between selenium metabolism and ferroptosis via PRDX6, the regulatory mechanism of inflammation and ferroptosis by ACSL4, which controls the unsaturation of membrane lipids, the molecular mechanism of membrane swelling and rupture in ferroptosis and the regulatory mechanism of cell death (lipoxytosis) via iron-independent lipid oxidation, etc., we will introduce the latest research on lipid oxidation-dependent cell death (ferroptosis).