Session Details
[S46]New Era in Pharmaco"Epi"genomics -Frontiers in Epigenetics from Basic Science to Drug Discovery-
Sat. Mar 29, 2025 1:30 PM - 3:00 PM JST
Sat. Mar 29, 2025 4:30 AM - 6:00 AM UTC
Sat. Mar 29, 2025 4:30 AM - 6:00 AM UTC
Room 6 (Fukuoka International Congress Center: 203 [2F])
Organizer: Tomoaki Koga (IMEG, Kumamoto Univ.), Takashi Minami (Div. Mol.Vasc.Biol, IRDA, Kumamoto Univ.), Ito Akihiro (Tokyo Univ. Pharm. Life Sci., Sch. of Life Sci.), Suzuki Takayoshi (SANKEN, Osaka Univ.)
[English Session]
Despite completing the Human Genome Project over 20 years ago and decoding genetic information, many uncertainties remain regarding the "utilization of genetic information," i.e. "Epigenomic information," and its connection to health and disease. Meanwhile, drugs targeting the epigenome, such as azacitidine and vorinostat, have already been launched and are widely recognized for their utility. Epigenetics, as such, is a highly socially relevant research field, but it cannot be said that it has been sufficiently discussed within the area of pharmaceutical sciences. Therefore, this symposium aims to define drug discovery research based on epigenomic information as "Pharmaco-'Epi'-genomics" and proposes it as a research area that includes fundamental epigenetic mechanisms, disease mechanisms, drug development, and the epigenomic characteristics of patients. For this symposium, we have invited Dr. Baek, a global leader in epigenetics research, and assembled speakers from multiple sections to create a joint symposium across different disciplines. Using the epigenome as a common language, we hope to foster seamless and passionate discussions that transcend boundaries, ranging from basic biopharmaceutical sciences to pharmacology and chemical biology. We aspire to ignite a new wave of epigenome-driven drug discovery through this interdisciplinary collaboration.
Introduction of “New Era in Pharmaco-Epigenomics ~Frontiers in Epigenetics from Basic Science to Drug Discovery”~:Tomoaki Koga(IMEG, Kumamoto Univ.)
[S46-1]Epigenetic Code in Health and Diseases
○Sung Hee Baek1 (1. Creative Res Initiatives Center for Epigenetic Code and Disease, Dept Biol Sci, Seoul National Univ.)
[S46-2]Epigenetic modifiers in inflammation and fibrosis
○Tomoaki Koga1, Naofumi Funagura1,2, Seonghyeon Hong1, Ayane Noda1, Toshihiro Inoue2, Mitsuyoshi Nakao1 (1. Dept. Med. Cell. Biol., IMEG, Kumamoto Univ., 2. Dept. Ophthalmol, Grad. Sch. Med., Kumamoto Univ.)
[S46-3]VEGF-mediated unique epigenetic modifications defined endothelial cells identification, angiogenesis, and inflammation through our health and disease states
○Takashi Minami1,2 (1. Div. Mol.Vasc.Biol, IRDA, Kumamoto Univ., 2. Div. Mol.Vasc.Biol., Faculty of Life Sci, Kumamoto Univ.)
[S46-4]Development of histone methyltransferase G9a inhibitors for the treatment of sickle cell disease
○Akihiro Ito1 (1. Tokyo Univ. Pharm. Life Sci., Sch. of Life Sci.)
[S46-5]Identification of epigenetic complex disrupters
○Takayoshi Suzuki1 (1. SANKEN, Osaka Univ.)