The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)
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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[29-25-pm]Chemical reaction development, mechanistic analysis, computational chemistry 14

Sun. Mar 29, 2026 1:10 PM - 3:10 PM JST
Sun. Mar 29, 2026 4:10 AM - 6:10 AM UTC
Room 25 (2304, Bldg. 2, Area 4 [3F])
Chair: Masatoshi Shibuya, Hiroyoshi Esaki
1:10 PM - 1:22 PM JST(4:10 AM - 4:22 AM UTC)

[29-25-pm01S]Investigation of the reaction mechanism for the microflow synthesis of sterically hindered peptides using C,N-terminal-free amino acids

○Motoharu Yamashita1, Dosaki Hinata1, Ting-Ho Chen1, Shinichiro Fuse1 (1. Grad. Sch. Pharm. Sci., Nagoya Univ.)
1:22 PM - 1:34 PM JST(4:22 AM - 4:34 AM UTC)

[29-25-pm02S]Light-controlled phosphate conjugation/removal reactions for unprotected peptides

○Yumi Shirotori1, Koki Ogawa1, Nanami Okada1, Hiroshi Takikawa1, Kenji Mishiro1 (1. Fac. Pharm. Sci, Kanazawa Univ.)
1:34 PM - 1:46 PM JST(4:34 AM - 4:46 AM UTC)

[29-25-pm03S]Asymmetric conjugate addition of azlactones to ynones using organocatalyst

○Yuta Iino1, Yasuyuki Matsushima1, Kosuke Nakashima1, Shin-ichi Hirashima1, Tsuyoshi Miura1 (1. Tokyo University of Pharmacy and Life Sciences)
1:46 PM - 1:58 PM JST(4:46 AM - 4:58 AM UTC)

[29-25-pm04S]The study on reactivity of nitrene under physiological conditions for protein modification

○Haruki Toyoshima1, Akitomo Kasahara1, Kenzo Yamatsugu1 (1. Grad. Sch. Pharm. Sci., Chiba Univ.)
1:58 PM - 2:10 PM JST(4:58 AM - 5:10 AM UTC)

[29-25-pm05S]Development of artificial cleavage reactions of polypeptides into amidated peptides

○Sayaka Tsuji1, Taka Sawazaki1, Youhei Sohma1 (1. Sch. of Pharm. Sci., Wakayama Med. Univ.)
2:10 PM - 2:22 PM JST(5:10 AM - 5:22 AM UTC)

[29-25-pm06]Histidine-selective modification utilizing phosphoimidazolide reagent

○Akitomo Kasahara1, Taiki Nakano1, Harunori Yoshikawa2, Kenzo Yamatsugu1 (1. Grad. Sch. Pharm. Sci., Chiba Univ., 2. Inst. Adv. Biosci., Keio Univ.)
2:22 PM - 2:34 PM JST(5:22 AM - 5:34 AM UTC)

[29-25-pm07S]Synthesis of peptoids containing unnatural N-alkyl-α,α-disubstituted amino acids

○Yusuke Suzuki1, Hisanori Nambu1, Keisuke Tomohara1 (1. Kyoto Pharm.Univ.)
2:34 PM - 2:46 PM JST(5:34 AM - 5:46 AM UTC)

[29-25-pm08S]Advanced Applications of Aerobic Oxidative Peptide Synthesis Using Nitroxyl Radical/Copper Catalysis

○Riki Yamakawa1, Shuhei Akutsu1, Shota Nagasawa1, Yusuke Sasano1, Yoshiharu Iwabuchi1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)
2:46 PM - 2:58 PM JST(5:46 AM - 5:58 AM UTC)

[29-25-pm09S]Development of a Cyclic Peptide Synthesis Method Based on Indole Ring Sulfenylation Using a Nitropyridine Sulfenate Ester

○Shimpei Kasama1, Akihiro Taguchi1,2, Hayate Shida2, Yuma Tokita2, Reo Kishi1, Haruki Miyashita1, Sho Konno1,2, Atsuhiko Taniguchi1,2, Yoshio Hayashi2,3 (1. Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 2. Grad. Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 3. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci.)
2:58 PM - 3:10 PM JST(5:58 AM - 6:10 AM UTC)

[29-25-pm10S]Thioflavin-T Demethylation Reaction Using Amyloid

○Eiga Uno1, Kai Yamamoto1, Taka Sawazaki1, Youhei Sohma1 (1. Sch. Pharm. Sci., Wakayama Med. Univ.)
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