講演情報
[24p-32A-11]Unraveling the mechanochromism of polydiacetylene by dual friction force/fluorescence microscopy
〇(DC)Jianlu Zheng1,2, Kaori Sugihara1,2 (1.UTokyo, 2.IIS)
キーワード：
friction force microscopy、fluorescence、biosensor
Polydiacetylene (PDA) is a special p-conjugated material widely used in sensing applications due to its facile polymerization and dual signals (visual color change and turn-on fluorescence) upon exposure to external stimuli. Recently, most people have tried to develop various biosensors to detect metal ions and biomolecules. However, the mechanochromism remains relatively and significantly less researched. For example, how much and which direction of force exactly twists the backbone and alters its optical properties is unknown, limiting the further tuning of these applications. In 2021, Sugihara Group (Nano Lett. 2021, 21, 543−549) first demonstrated quantitative and anisotropic force-fluorescence correlation of PDA thanks to a unique setup in the lab, nano-friction force/fluorescence microscopy. We expanded this technique under aqueous solution to study the local correlation between fluorescence and force of PDA at the nanoscale (Anal. Chem. 2023, 95, 11335−11341). In addition, it is possible to quantify the angle-dependent mechanochromism. Our results will make all the previous sensing performed by this mechanochromic polymer more understood, which will open a new pathway for developing easy-to-use (naked-eye detection) point-of-care diagnostic tools.