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[1P-264] Improving AAV Purity and Yield: A Multicolumn Countercurrent Solvent Gradient Purification for Full AAV Particle Isolation

*Yuki Higuchi¹, Julia M. Müller^2,3, Tereza Müllerová², Daniela Tobler², Damian Hauri², Richard Plieninger², Ryosuke Takahashi¹, Sebastian Vogg⁴, Thomas Müller-Späth⁴, Thomas K. Villiger² (1. YMC CO., LTD., Kyoto, Japan, 2. Institute of Pharma Technology, University of Applied Sciences Northwestern Switzerland, Muttenz, Switzerland, 3. Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland, 4. ChromaCon AG, Zürich, Switzerland)

キーワード：

continuous chromatography、viral vector、AAV、gene therapy

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