Presentation Information
[2P43]Development of a novel sputtering-based tablet coating technique for enhanced photo-stability of pharmaceutical compounds
*Kayo Yuminoki1, Tatsuya Honjo1, Isamu Saeki1, Yutaka Okuda1 (1. Towa Pharmaceutical Co., LTD.)
Tablet coating is widely used to improve the photo-stability of oral dosage forms. However, conventional spray film coating (SFC) increases coating thickness, which may delay tablet disintegration. In this study, we explored the feasibility of sputtering, -a dry process capable of nanometer-scale film deposition-, as an alternative coating method. Tablets containing a photo-labile drug were coated with Fe2O3 using either SFC or sputtering. The SFC prepared tablets (SFC-T) exhibited increased hardness and prolonged disintegration time due to the film agent. In contrast, the sputter-coated tablets (SPU-T) retained their original physical properties. Furthermore, SPU-T also showed superior photo-stability compared to SFC-T. These results suggest that sputtering provides an ultra-thin, uniform coating without the film agents, thereby preserving tablet characteristics while enhancing light-shielding. Sputtering is therefore a promising approach for stabilizing pharmaceutical formulations.