Session Details
[29P]Absorption/Transpoters/Distribution and excretion · Metabolism/ADME, PK/PD, Drug interaction
Sat. Mar 29, 2025 8:30 AM - 3:00 PM JST
Sat. Mar 29, 2025 11:30 PM - 6:00 AM UTC
Sat. Mar 29, 2025 11:30 PM - 6:00 AM UTC
Poster (MARINE MESSE FUKUOKA Hall B: Exhibition Room [1F])
[29PA-168]Factors influencing bioequivalence studies for topical patch formulations
○Daisuke Mori1, Takamitsu Miyagi2, Tomohiro Hikima3 (1. Biocom Systems, 2. Sch. Pharm., Shujitsu Univ., 3. Grad. Sch. Comp. Sci. Syst. Eng., Kyutech)
[29PB-169]Development of nanoparticle-loaded dissolving microneedle by droplet extension technology: strategic application to poorly water-soluble compounds
○Hideyuki Sato1, Monami Sugihara1, Akihiko Ogasawara2, Tadanobu Yonemoto2, Kohei Yamada1, Satomi Onoue1 (1. Lab. of Biopharm., Sch. of Pharm. Sci., Univ. of Shizuoka, 2. Raphas Co., Ltd.)
[29PA-170S]Influence of carboxylesterase on percutaneous absorption of dibutyl phthalate in human
○Hinako Shindo1, Shoma Miyamori1, Ruka Jinbo1, Midori Oyama1, Takashi Tanikawa1, Tomoharu Takeuchi1,2, Akio Kondoh3, Tomotaka Mabuchi3, Tomomi Hatanaka1,3 (1. Fac. Pharm. & Pharm. Sci., Josai Univ., 2. Sch. Pharm., Aichi Gakuin Univ., 3. Sch. Med., Tokai Univ.)
[29PB-171]Region-Specific Evaluation of ADME Functions in Monolayer-Cultured Dog Intestinal Cells
○Hiroyuki Kusuhara1, Koki Takezaki1, Yoshiki Hashimoto1, Masaki Kinehara2, Junko Sakagami2, Kazuya Maeda1,3 (1. Grad. Sch. Pharm. Sci., Univ. of Tokyo, 2. Nikon Corp., 3. Sch. Pharm., Kitasato Univ.)
[29PA-172]Comprehensive prediction of in vivo absorption of marker compounds from the liver surface by in vitro study based on dialysis membrane permeation
○Koyo Nishida1, Yuan Fei1, Ayaka Torigoe1, Nao Mitsudome1, Jia Zhou1, Hirotaka Miyamoto1, Shintaro Fumoto1 (1. Grad. Sch. Biomed. Sci., Nagasaki Univ.)
[29PB-173]Research toward developing an oral formulation of exercise-induced feeding inhibitor (N-lactoyl-phenylalanine).
○Masataka Tajima1, Takayuki Kanaya2, Erika Sugiyama1, Hitoshi Sato1 (1. Grad. Sch. Pharm. Sci., Showa Univ. , 2. Sch. Pharm., IUHW)
[29PA-174S]Pharmacokinetic analysis of small molecule compounds after intraperitoneal administration using a mouse colorectal cancer peritoneal dissemination model
○Misaki Ishida1, Yuta Tamemoto1, Hiroto Hatakeyama1 (1. Grad. Sch. Pharm. Sci., Chiba Univ.)
[29PB-175]Correlation between skin penetration and stratum corneum structure of Camellia japonica oil from Saga prefecture.
○Nozomi Honma1,2, Yoshihiro Tokudome1 (1. Saga Univ., 2. Saga Prefecture Industrial Innovation Center)
[29PA-176S]Verification of Therapeutic Effects of Transdermal Delivery of Osteoporosis Drugs Using Pulse Current Iontophoresis
○Ryuse Sakurai1, Ritsuki Okada1, Issei Takeuchi2, Akiyoshi Saitoh1 (1. Grad. Sch. Pharm. Sci., Tokyo University of Science, 2. Fac. Pharm. Sci., Josai International Univ.)
[29PB-177S]Effect of beverage containing indigestible dextrin on intestinal absorption of anticoagulant drugs
○Naoya Takano1, Hideki Takakura1, Yuka Kuba1, Aki Katou1, keisuke Oda1 (1. Fac. Pharm. Sci., Hiroshima International Univ.)
[29PA-178S]Study on the pharmacokinetics of catechin and effect on transporter activity by catechin in the presence of stabilizing agents
○Yui Hirayama1, Hideki Takakura1, Rio Fujioka1, Naho Tanimoto1, Keisuke Oda1 (1. Fac. pharm. Sci., Hiroshima International Univ.)
[29PB-179S]Optimal dose/fluid volume ratio in dissolution test for predicting oral absorption of drugs
○Yuki Tarumi1, Kiyohiko Sugano1 (1. Ritsumeikan University)
[29PA-180S]Baicalein nanostructured lipid carriers in cosmetic applications and bioactivity research
○Yun-Xuan Tseng1, Tzu-Hui Wu2, Feng-Lin Yen3 (1. Department of Biotechnology , College of Pharmacy, Kaohsiung Medical University, 2. Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, 3. Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University)
[29PB-181S]The distribution of 5-aminosalicylic acid into the intestinal membrane along the gastrointestinal tract after oral administration in rats.
○Yuta Gotou1, Fumiya Ohnishi1, Syoutarou Koga1, Goroumaru Takeshi, Yorinobu Maeda1 (1. Fukuyama Univ.)
[29PA-182S]Development and Skin Permeation of a Novel Pregabalin Transdermal Formulation
○Rina Sakama1, Michiru Nagao1,2, Masataka Tajima1, Masayuki Yoshikawa2, Hitoshi Sato1, Erika Sugiyama1 (1. Grad. Sch. Pharm. Sci., Showa Univ., 2. Department of Hospital Pharmaceutics, School of Pharmacy, Showa Univ.)
[29PB-183S]Functional of pH dependent fluorescein transporter in HK-2 cells that can recognize various dicarboxylates
○Aoi Kato1, Chiharu Tanaka2, Yuta Kuniya2, Takuya Fujita3, Tetsuya Kajimoto3, Seiji Miyauchi1,2 (1. Grad. Sch. Pharm. Sci., Toho Univ., 2. Fac. Pharm. Sci., Toho Univ., 3. Col. Pharm. Sci., Ritsumeikan Univ.)
[29PA-184S]Functional characterization of ATP13A3 as a plasma membrane polyamine transporter: analysis of spermidine transport function
○Haruka Tanaka1, Haruka Morimoto1, Takuma Ishihara1, Tomoya Yasuzima1, Takahiro Yamashiro1, Hiroaki Yuasa1 (1. Grad. Sch. Phatm. Sci., Nagoya City Univ.)
[29PB-185]Exploration of novel human organic cation transporter 2 inhibitors using a machine learning-based quantitative structure-activity relationship model
○Kenji Ikemura1,2, Fumihiro Yamane3, Masayoshi Kondo3, Manami Ueno3, Masahiro Okuda1,2 (1. Dept. Pharm., Osaka Univ. Hosp., 2. Grad. Sch. Med., Osaka Univ., 3. Sch. Pharm. Sci., Osaka Univ.)
[29PA-186]Proteomic analysis reveals mechanism of antitumor-active platinum(II) dinuclear complex overcoming cross-resistance to oxaliplatin
○Masako Uemura1,2, Seiji Komeda1,2 (1. Fac. Pharm. Sci., Suzuka Univ. Med. Sci., 2. Grad. Sch. Pharm., Suzuka Univ. Med. Sci.)
[29PB-187S]Folate transport function of OAT2 potentially involved in its hepatic disposition
○Misaki Inaba1, Yuuka Ogawa1, Tomoya Yasujima1, Takahiro Yamashiro 1, Hiroaki Yuasa1 (1. Grad. Sch. Pharm. Sci., Nagoya city univ.)
[29PA-188S]Effect of inflammation on drug transporter expression using human kidney biopsies and 3D-RPTEC
○Moeno Kadoguchi1, Megumi Oshima2, Etsushi Takahashi3, Hiroko Ikeda4, Minaho Yamauchi1, Ikumi Tamai1, Sumio Ohtsuki5, Yasunori Iwata2, Hiroshi Arakawa1 (1. Faculty of Pharm. Sci., Kanazawa Univ., 2. Faculty of Medicine, Kanazawa Univ., 3. Nikkiso Co., Ltd., 4. Department of Pathology, Kanazawa Univ. Hospital, 5. Faculty of Pharm. Sci., Kumamoto Univ.)
[29PB-189S]A novel rat hepatocyte culture system with open-form bile canaliculus for rapid evaluation of biliary drug excretion
○Momoka Hayashi1, Yuya Nakazono1, Ikumi Tamai1, Hiroshi Arakawa1 (1. Faculty of Pharm. Sci., Kanazawa Univ.)
[29PA-190S]Analysis of the amiloride transport function of SLC35F2.
○Riku Yamauchi1, Takahiro Yamashiro1, Tomoya Yasujima1, Hiroaki Yuasa1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ.)
[29PB-191S]Screening for novel syncytiotrophoblast-specific transporters in the placenta
○Ryusei Takei1, Saki Noguchi1, Takuro Ishinabe1, Toshiaki Tsuchitani1, Tomohiro Nishimura1,2, Masatoshi Tomi1 (1. Facult. Pharm., Keio Univ., 2. Facult. Pharm., Juntendo Univ.)
[29PA-192S]Expression and localization of Oatp2b1 in the placenta of full-term pregnant rats
○Sawako Hasegawa1, Tomohiro Nishimura1,2, Keisuke Orii1, Saki Noguchi1, Masatoshi Tomi1 (1. Facult. Pharm., Keio Univ.,, 2. Facult. Pharm., Juntendo Univ.,)
[29PB-193S]Functional characteristics of ENT3 as a lysosomal urate transporter and its role in urate clearance potentially involved in gout prevention
○Sayumi Tanikoshi1, Isamu Matake1, Tomoya Yasujima1, Takahiro Yamashiro1, Hiroaki Yuasa1 (1. Grad. Sch. Pharm. Sci., Nagoya City Univ.)
[29PA-194]Impact of creatine deficiency on cellular function in fibroblasts with SLC6A8 mutations derived from Japanese patients"
○Shingo Ito1,2, Tatsuki Uemura2,3, Aayaka Miyano2, Hiroko Shimbo4, Takeshi Masuda1,2,5, Tomohide Goto4, Hitoshi Osaka6, Takahito Wada7, Sumio Ohtsuki1,2 (1. Fac. Life Sci. Kumamoto Univ., 2. Grad. Sch. Pharm. Sci., Kumamoto Univ., 3. Nippon Med. Sch. Adv. Med., 4. Kanagawa Child. Med. Ctr., 5. Keio Univ. Adv. Biosci., 6. Jichi Med. Univ., 7. Grad. Sch. Med., Kyoto Univ.)
[29PB-195S]Screening of SLC transporter substrates included in Sake lees from the Noto region by metabolome analysis to explore health nutrients
○Shion Kanehara1, Yusuke Masuo1, Yukio Kato1 (1. Faculty of Pharmacy, Kanazawa University)
[29PA-196]Effect of Sambucus nigra L. extract on transport activity of OATP2B1.
○Shuhei Takano1, MIsako Ishihara1, Kazuya Maeda1 (1. KITASATO Univ.)
[29PB-197S]Serotonin transport function of a novel monoamine transporter highly expressed in astrocytes:comparison with the function of SERT
○Taisei Oka1, Takuma Ishihara1, Tomoya Yasujima1, Takahiro Yamashiro1, Hiroaki Yuasa1 (1. Grad.Sch.Pharm.Sci.,Nagoyacity Univ.)
[29PA-198]Significant increases in detection capability of OATP1B1 and 1B3 mediated drug-drug interaction by minimizing impact of precursors of Coproporphyrin I and III
○Takuho Ishii1,2, Yuji Mano2,3 (1. Sunplanet, 2. Grad. Sch. Com. Hum. Sci., Univ. of Tsukuba, 3. Eisai)
[29PB-199]Development of in vitro BBB model using human iPS cells-derived cells
○Tomoko YAMAGUCHI1, Misae NISHIJIMA1, Kenji KAWABATA1,2 (1. NIBIOHN, 2. Grad. Sch. Pharm. Sci., Osaka Univ.)
[29PA-200]Effects of iron compounds on PCFT-mediated folate transport
○Tomoya Narawa1, Hinako Enomoto1, Kazuya Maeda1 (1. School of Pharmacy, Kitasato University)
[29PB-201]Excessive accumulation of phytosterols resulting from ABCG5/G8 dysfunction deteriorates egg function and induces female infertility
○Yoshihide Yamanashi1, Toko Komine1, Hiroshi Suzuki1, Tappei Takada1 (1. Dept. Pharm., Univ. Tokyo Hosp.)
[29PA-202]Changes of ABC transporter expression by aging in blood-brain barrier of mouse
○Yukiyo Wada1, Masaki Inoko1, Kanako Ishihara1, Karin Fukumoto1, Yuya Tsurudome1, Michiko Horiguchi1,2, Akio Fujimura1,3, Kentaro Ushijima1,3 (1. Faculty. Pharm. Sci., Sanyo-Onoda City Univ., 2. Faculty. Engr. Sci., Sanyo Onoda City Univ., 3. Jichi Medical Univ.)
[29PB-203][Withdrawn]
[29PA-204]The effect of chlorpheniramine and diphenhydramine on the expression of drug-metabolizing enzymes in Caco-2 cells.
○Ayaka Kojima1, Hina Abiko1, Yuichi Uwai1, Tomohiro Nabekura1 (1. Sch. Pharm., Aichi-Gakuin Univ.)
[29PB-205]Effects of dexamethasone on cefoperazone pharmacokinetic changes induced by LPS administration
○Ayano Hibi1, Miki Katoh1, Masayuki Nadai1 (1. Fac. Pharm., Meijo Univ.)
[29PA-206]Collaborative changes in the expression of drug-metabolizing enzymes and transporters associated with altered expression of CYP3A
○Chieri Fujino1, Satoshi Ueshima1, Toshiya Katsura1 (1. College of Pharm. Sci., Ritsumeikan Univ.)
[29PB-207S]The effect of partial cooling on docetaxel concentration in skin
○Maho Ito1, Miyu Fukada1, Genki Minegishi1, Miyuki Hirata1, Atsushi Miyajima1, Kaoru Kobayashi1 (1. Meiji Pharm.Univ.)
[29PA-208]Effects of nilotinib and radotinib on cytochrome P450 2C8 and 2J2
○Miki Katoh1, Ayaka Kojima1, Masayuki Nadai1 (1. Meijo Univ)
[29PB-209][Withdrawn]
[29PA-210]Blockage of retinal excitotoxicity by peripheral injection of a drug recognized by amantadine-sensitive transport systems at the inner blood-retinal barrier
Yusuke Shinozaki1, Shin-ichi Akanuma1, Yuma Tega1, ○Ken-ichi Hosoya1 (1. University of Toyama)
[29PB-211S]A Prospective Proposal on Variability Management of In Vitro Blood-Brain Barrier Models Using HBMEC/ci18 Cells with Different Passage Numbers
○Fukuda Mei1, Ohki Seiya1, Baba Tomoyo1, Wakayama Naomi2, Morio Hanae1, Yamaura Yoshiyuki3, Komori Takafumi2, Furihata Tomomi1 (1. Tokyo Univ Pharm & Life Sci., 2. Eisai Co., Ltd, 3. Ono Pharmaceutical Co., Ltd.)
[29PA-212S]Effect of metronidazole on the anticoagulant effect and plasma concentration of warfarin
○Hirotaka Ito1, Hina Okubo1, Reo Kameoka1, Toshiyuki Kudo1,2, Yoshiaki Yamagishi1,2, Kiyomi Ito1,2 (1. Fac. Pharm., Musashino Univ., 2. Res. Inst. Pharm. Sci., Musashino Univ.)
[29PB-213S]Comparison of inhibitory kinetics of vonoprazan on the metabolic activation of clopidogrel among CYP2C19 variants
○Kohei Ouchi1, Norika Shimada1, Hiroyuki Seki2, Ayuko Imaoka1,3, Miyuki Shimoji4, Katsunori Nakamura4, Hiroshi Yamazaki5, Takeshi Akiyoshi1,3, Hisakazu Ohtani1,3,6 (1. Fac. Pharm., Keio Univ., 2. Dept. Pharm., Tsukuba Univ. Hosp. , 3. Sch. Med., Keio Univ., 4. Dept. Pharm., Ryukyu Univ. Hosp., 5. Sch. Pharm., Showa Pharmaceutical Univ., 6. Dept. Pharm., Keio Univ. Hosp.)
[29PA-214S]Development of a microdialysis coupled with the LC-MS/MS system for the pharmacokinetics of anti-monkeypox drug tecovirimat
○Li-Wen Wang1, Chung-Kai Sun1, Yen-Ying Kung1,2, Shih-Hwa Chiou3,4, Tung-Hu Tsai1 (1. Institute of Traditional Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, 2. Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, 3. Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, 4. Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan)
[29PB-215]Investigation of drug-drug interactions of Japanese traditional medicine Goreisan using CYP3A-humanized mice
○Mari Hida1, Mitsue Nishiyama1, Akinori Nishi1, Yasuhiro Kazuki2,3, Kaoru Kobayashi4 (1. Tsumura & Co., 2. Sch of Life Sci, Fac Med, Tottori Univ, 3. Chr Engr Res Ctr, Tottori Univ, 4. Meiji Pharm Univ)
[29PA-216S]Pharmacokinetic-toxicodynamic model of olaparib-induced myelosuppression for dose optimization
○Moe Ushijima1, Shinji Kobuchi1, Toshiyuki Sakaeda1, Yukako Ito1 (1. Kyoto Pharm. Univ.)
[29PB-217]A new method for predicting plasma concentration-time profile from pharmacokinetic parameters in package inserts
○MOTOHIRO KATO1 (1. DMPK academy)