罫線.png

罫線1

250805_創薬サイエンス_バナーRGB_250-110.gif

創薬サイエンス

【AMED】日本薬学会第146年会.gif

日本医療研究開発機構

【UBE】_バナー広告_ロゴ.gif

UBE株式会社

東ソーロゴバナー（250px × 93px）.jpg

東ソー

【安井機械】banner_250x110.jpg

安井器械株式会社

【修正版】【BINDS】H110W250_日本薬学会第146年会_BINDSハ゛ナー広告_0212.png

BINDS

入稿データ_生命科学連携推進協議会.gif

生命科学連携推進協議会

General information

Overview

Access

Pharmaceutical International Meeting

Announcements(33)

Best Student Presentation Award

Timetable

Fri. Mar 27, 2026

Sat. Mar 28, 2026

Sun. Mar 29, 2026

Program & Abstract

Sessions

Search presentations

Download PDF for print

Selected programs of presentations in English

Registration

Registration (Non-presenters, UG ≤ 4th Year)

For Participants

Participation Certificate PDF

Floor Guide

How to use "Confit mobile meeting app"

For Presenters

Exhibition

Companies（Equipment exhibits）

Companies（Medical supplies）

Companies (Literature Search Systems)

Companies（Books）

Abstract Submission (Oral/Poster Presentation)

Abstract Submission

146_head_en.png

app_icon.png

Change account information such as the email address and password on the account setting screen common to Confit.

Login required to view

Password required to view

Presentation Information

Session Details

Enter the password to view the abstracts.<br>The password will be emailed to those who have completed the registration.

To browse or post comments, you must log in.

You cannot post comments as it is outside the comment posting period.

This comment has been deleted. You cannot reply to this comment.

Program Type

General Session Category

Profile management

Bookmark

Announcements

Risk assessment of cardiotoxicity in anticancer agents focusing on cardiac mitochondria

Advances in cancer therapy have improved long-term survival; however, the increasing incidence of cancer therapy–related cardiovascular toxicity has become a major concern. Diverse cardiotoxicities associated with anthracyclines, molecularly targeted agents, and immune checkpoint inhibitors have been reported, yet the systematic collection of cardiovascular events in oncology trials remains insufficient. Treatment modifications and the presence of late-onset cardiotoxicity further complicate clinical assessment. Evidence regarding the efficacy and safety of cardioprotective agents, as well as their interactions with anticancer drugs, also remains limited. These clinical challenges highlight the need touse New Approach Methodologies in non-clinical testing.<br />   This symposium will discuss how clinical needs can be effectively integrated into preclinical evaluations. Key topics include mitochondrial and structural toxicity assessment using human iPSC-derived cardiomyocytes, characteristic toxicity profiles of anticancer drug classes, and the role of intracellular quality control mechanisms. We will also address data-driven approaches that combine real-world data, pharmacokinetic and genomic information, and animal studies, applying machine learning to identify cardiotoxicity risk factors.<br />   Thus, by bridging basic science, clinical practice, and regulatory science, this symposium aims to support safer cancer therapy through improved prediction and prevention of anticancer drug-induced cardiotoxicity.

Advancing Regulatory Science in Cardio-Oncology: Bridging Basic Science and Clinical Practice

The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

Presentation Information

[S30-2]Risk assessment of cardiotoxicity in anticancer agents focusing on cardiac mitochondria

Password required to view