The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)
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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[27-13-pm]Chemical biology 1

Fri. Mar 27, 2026 1:10 PM - 3:10 PM JST
Fri. Mar 27, 2026 4:10 AM - 6:10 AM UTC
Room 13 (C404)
Chair: Tetsuo Narumi, Tetsuya Kadonosono
1:10 PM - 1:22 PM JST(4:10 AM - 4:22 AM UTC)

[27-13-pm01S]Development of light-activatable cyclic peptides that inhibit intracellular p53/MDM2 protein-protein interaction

○Kazuma Arakawa1, Yosuke Hisamatsu1, Ryosuke Ishida1, Naoki Umezawa1 (1. Grad. Sch. Pharm. Sci., Nagoya city Univ.)
1:22 PM - 1:34 PM JST(4:22 AM - 4:34 AM UTC)

[27-13-pm02S]Development of novel small-molecule prodrugs to induce cardiac-specific regeneration after myocardial infarction

○Shotaro Inoue1, Kyohhei Fujita2, Kentaro Hirose3,4, Hirotsugu Tsuchimochi4, Yasuteru Urano1,2 (1. Grad. Sch. Pharm. Sci., Tokyo Univ., 2. Grad. Sch. Med., Tokyo Univ., 3. CSCI., Cambridge Univ., 4. Natl. Cerebral and Cardiovascular Ctr. Res. Inst.)
1:34 PM - 1:46 PM JST(4:34 AM - 4:46 AM UTC)

[27-13-pm03S]Amyloid-Catalyzed Lysine Modification Reaction

○Toshiyuki Seki1, Taka Sawazaki1, Youhei Sohma1 (1. Sch. Pharm. Sci., Wakayama Med. Univ.)
1:46 PM - 1:58 PM JST(4:46 AM - 4:58 AM UTC)

[27-13-pm04S]Chemical synthesis of TDP-43 with phosphorylation modification in the intrinsically disordered region

○Sara Kitajima1, Mao Tenda1, Daisuke Sasaki1, Youhei Sohma1 (1. Sch. Pharm. Sci., Wakayama Med. Univ.)
1:58 PM - 2:10 PM JST(4:58 AM - 5:10 AM UTC)

[27-13-pm05S]Chemical Synthesis and Functional Evaluation of a Miniature Luciferase picALuc for Structural and Functional Analyses

○Yukino Sato1, Hana Nakahashi1, Naoya Iwamoto1, Shinya Oishi1 (1. Kyoto Pharm. Univ.)
2:10 PM - 2:22 PM JST(5:10 AM - 5:22 AM UTC)

[27-13-pm06]Metal-Responsive Up-regulation of Bifunctional Disulfides for Promoting Oxidative Folding

○Takahiro Muraoka1, Keita Mori1, Masaki Okumura2, Tsubura Kuramochi2, Tomohide Saio3, Motonori Matsusaki3, Yoshiaki Furukawa4, Yuki Hashiguchi4, Kenta Arai5 (1. Tokyo University of Agriculture and Technology, 2. Tohoku University, 3. Tokushima University, 4. Keio University, 5. Tokai University)
2:22 PM - 2:34 PM JST(5:22 AM - 5:34 AM UTC)

[27-13-pm07S]Redox-Active Micelles for Promoting Oxidative Protein Folding at High Concentrations

○Mai Kitamura1, Tomohide Saio2, Masaki Okumura3, Takahiro Muraoka1 (1. Grad. Sch. of Eng., Tokyo Univ. of Agri. and Tech., 2. IAMS, Tokushima Univ., 3. FRIS, Tohoku Univ.)
2:34 PM - 2:46 PM JST(5:34 AM - 5:46 AM UTC)

[27-13-pm08S]Near-infrared-responsive photocatalyst enables non-invasive in vivo amyloid-β oxygenation through nose-to-brain delivery

○Menghan Xu1, Sena Yamaguchi1, Yuma Takeuchi1, Yuki Yamanashi1, Motomu Kanai1 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)
2:46 PM - 2:58 PM JST(5:46 AM - 5:58 AM UTC)

[27-13-pm09S]Proximity labeling of the substrates of caseinolytic protease P using a photocrosslinking probe

○Taketo Imai1, Fumihiro Ishikawa1,2, Naoto Shobayashi2, Takehiro Suzuki3, Naoshi Dohmae3, Genzoh Tanabe1,2,4 (1. Graduate School of Pharmacy, Kindai University , 2. Faculty of Pharmacy, Kindai University, 3. Biomolecular Characterization Unit, Center for Sustainable Resource Science, RIKEN, 4. Pharmaceutical Reasearch and Techology Institute, Kindai University)
2:58 PM - 3:10 PM JST(5:58 AM - 6:10 AM UTC)

[27-13-pm10]Understanding the physiological and metabolic significance of acrolein production in cancer cells

○Hiromasa Yoshioka1, Ambara R. Pradipta2, Katsunori Tanaka1,2 (1. PRI, RIKEN, 2. Sch. Mat. and Chem. Tech., Science Tokyo)
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