The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)
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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[27-14-pm]Drug discovery, structure-activity relationship 1

Fri. Mar 27, 2026 1:10 PM - 3:10 PM JST
Fri. Mar 27, 2026 4:10 AM - 6:10 AM UTC
Room 14 (C507)
Chair: Shinya Fujii, Yoshihiro Sohtome
1:10 PM - 1:22 PM JST(4:10 AM - 4:22 AM UTC)

[27-14-pm01S]Development of H-PGDS-Targeting PROTACs Focusing on Linker Structures

○Hinata Osawa1,2, Kosuke Saito2, Yosuke Demizu1,2,3 (1. Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ., 2. NIHS., 3. Grad. Sch. Med. Life Sci., Yokohama City Univ.)
1:22 PM - 1:34 PM JST(4:22 AM - 4:34 AM UTC)

[27-14-pm02]IInvestigation of the antibacterial activity of Trp-Pro-Arg-myticalin A6 (3–23)-Trp-Pro-Arg-OH substituted with Trp at positions 9 or 12 derivatives

○Keiko Okimura1, Tatsuo Takahashi1, Miyu Sugimoto1, Azumi Hashizume1, Tohru Daikoku1 (1. Fac. Pharm. Sci., Hokuriku Univ.)
1:34 PM - 1:46 PM JST(4:34 AM - 4:46 AM UTC)

[27-14-pm03]Synthesis of KDEL Receptor Inhibitors and Evaluation of Their Antitumor Activity

○Kaori OTA1, Takanori Kitaguchi2, Taichi Matsumoto2, Toshiyuki Tsunoda2, Makoto Furutachi1 (1. Pharm. Sci., Fukuoka Univ., 2. Med., Fukuoka Univ.)
1:46 PM - 1:58 PM JST(4:46 AM - 4:58 AM UTC)

[27-14-pm04S]Structural Optimization of Drug Linkers with Cysteine Derivatives and Their Application to Novel Antibody-Drug Conjugates

○Taiki Ichida1, Naohisa Ogo1, Keisuke Murase1, Katsumi Ohta1, Jun-ichi Sawada1, Hisashi Murakami1, Akira Asai1 (1. Grad. Div. Pharm., Univ. of Shizuoka)
1:58 PM - 2:10 PM JST(4:58 AM - 5:10 AM UTC)

[27-14-pm05S]Structure-Activity Relationship Study of Cyclic Tetrapeptides Exhibiting Antimalarial Activity

○Taichi Okano1, Hiroki Nakahara1, Goh Sennari1,2, Aki Ishiyama1,2, Rei Hokari1,2, Toshiaki Sunazuka1,2, Tomoyasu Hirose1,2, Masato Iwatsuki1,2 (1. Grad. Sch. Infection Control Sci., Kitasato Univ., 2. Ōmura Satoshi Memorial Inst., Kitasato Univ.)
2:10 PM - 2:22 PM JST(5:10 AM - 5:22 AM UTC)

[27-14-pm06S]Silicon-Modified Solid-Phase Synthesis for Rapid PROTAC Discovery

○Ayano Ito1, Hiroyuki Yamakoshi1,2,3, Ryo Watanabe2, Takayuki Doi1,2,3, Yoshiharu Iwabuchi1,2,3 (1. Fac. Pharm. Sci., Tohoku Univ., 2. Grad. Pharm. Sci., Tohoku Univ., 3. Dev. Pharm., Research Cent.)
2:22 PM - 2:34 PM JST(5:22 AM - 5:34 AM UTC)

[27-14-pm07S]Structure-activity relationship study on hydrophobic tag–based HDAC degraders for their rational design

○Mirei Hayashi1, Yukihiro Itoh1,2, Yasunobu Yamashita1, Yuri Takada1, Takayoshi Suzuki1 (1. SANKEN, Osaka Univ., 2. LBB, IIR, Science Tokyo)
2:34 PM - 2:46 PM JST(5:34 AM - 5:46 AM UTC)

[27-14-pm08]Study of new angucyclinones produced by Indonesian actinomycete IDNA-0041

○Elyza Aiman Azizah Nur1, Satoshi Ohte1, Satoru Shigeno1, Keisuke Kobayashi1, Herlina Rante2, Nana Juniarti Natsir Djide2, Hiroshi Tomoda1, Taichi Ohshiro1 (1. Grad. Sch. Pharm. Sci., Kitasato University, 2. Fac. Pharm., Hasanuddin University)
2:46 PM - 2:58 PM JST(5:46 AM - 5:58 AM UTC)

[27-14-pm09S]Development of Novel Antibacterial Modalities ‘vivoEF’ Inhibitors against P. aeruginosa

○Mao Yamamoto1, Risa Suzuki1, Toyotaka Sato2, Motohiro Horiuchi2, Kazuki Yamamoto1, Satoshi Ichikawa1 (1. Fac. Pharm. Sci., Hokkaido Univ., 2. Fac. Vet. Med., Hokkaido Univ.)
2:58 PM - 3:10 PM JST(5:58 AM - 6:10 AM UTC)

[27-14-pm10S]Development of A Vitamin D Derivative, Dcha-20 and Its Prodrugs as Novel Rodenticide

○Chiharu Ogura1, Miyuna Yoshihara1, Misaki Fukamatsu2, Ryo Kamata2, Kazuki Takeda2,3, Satoru Nagaoka4, Hiroyuki Kagechika5, Aya Tanatani1 (1. Dept. Chem., Fac. Sci., Ochanomizu Univ., 2. Sch. Vet. Med., Kitasato Univ., 3. Sch. Comput., Inst. Sci. Tokyo, 4. Daimaru Compound Chemical CO., LTD., 5. Lab. Biomater. Bioeng., Inst. Integ. Res., Inst. Science Tokyo)
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