The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

Organizer: Fumihiro Ishikawa (Fac. Pharm., Kindai Univ.), Shinichi Sato (FRIS, Tohoku Univ., Grad. Sch. Life Sci., Tohoku Univ.)

Biological phenomena are underpinned by the diverse and highly sophisticated molecular functions executed by proteins. These functions are governed not only by static three-dimensional structures but also by structural dynamics—the temporally and spatially regulated conformational changes that proteins undergo. Enzymatic reactions, signal transduction, molecular recognition, membrane transport, and many other cellular processes are intimately linked to protein structural flexibility and dynamic behavior. To elucidate and precisely control these processes, chemical approaches that allow molecular-level intervention in proteins have emerged as powerful strategies, offering exceptional spatial and temporal selectivity and enabling manipulation of phenomena that have been difficult to access using conventional methods. In this symposium, under the theme "Shaping the Future of Protein Science Through Molecular Technologies," leading researchers will present and discuss new perspectives in chemistry-driven protein science, covering a wide range of topics including imaging, covalent drug discovery, proteomics, intracellular delivery, single-molecule analysis, and antibody aggregation.