The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)
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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[27-29-pm]Genes, biosynthesis 2

Fri. Mar 27, 2026 1:10 PM - 3:10 PM JST
Fri. Mar 27, 2026 4:10 AM - 6:10 AM UTC
Room 29 (3401)
Chair: Yasuyuki Yamada, Shinji Kishimoto
1:10 PM - 1:22 PM JST(4:10 AM - 4:22 AM UTC)

[27-29-pm01S]Functional analysis of a pseudokinase responsible for nitrile formation in calyculin A

○Yuito Yamada1, Yokoyama Hiromi1, Matsuda Kenichi1, wakimoto toshiyuki1 (1. Grad. Sch. Pharm. Sci., Hokkaido Univ.)
1:22 PM - 1:34 PM JST(4:22 AM - 4:34 AM UTC)

[27-29-pm02S]Screening and Characterization of Penicillin-Binding Protein–Type Thioesterases, a Nonribosomal Peptide Cyclase Family

○Hiromi Yokoyama1, Shinya Niikura1, Ryusei Ueda1, Rintaro Ichihara1, Masakazu Kobayashi1, Kenichi Matsuda1, Toshiyuki Wakimoto1 (1. Grad. Sch. Pharm. Sci., Hokkaido Univ.)
1:34 PM - 1:46 PM JST(4:34 AM - 4:46 AM UTC)

[27-29-pm03S]An Atypical Non-Ribosomal Peptide Cyclase that Employs a Cyclic Amine Nucleophile

○Mitsuo Aono1, Yuito Yamada2, Kenichi Matsuda2, Toshiyuki Wakimoto2 (1. 1.Fac. Pharm. Sci., Hokkaido Univ., 2. Grad. Sch. Pharm. Sci., Hokkaido Univ.)
1:46 PM - 1:58 PM JST(4:46 AM - 4:58 AM UTC)

[27-29-pm04]Structural Basis of the Thiamine Pyrophosphate–Dependent Decarboxylation of an α-Iminocarboxylic Acid by AzcB/C

○Yu Nakashima1, Akari Umezawa2, Takeshi Tsunoda3, Yasushi Ogasawara3, Tohru Dairi3, Hiroyuki Morita1 (1. Univ. of Toyama, Inst. Nat. Med., 2. Grad. Sch. Chem. Sci. & Eng., Hokkaido Univ., 3. Grad. Sch. Eng., Hokkaido Univ.)
1:58 PM - 2:10 PM JST(4:58 AM - 5:10 AM UTC)

[27-29-pm05]Characterization of a PLP-dependent enzyme catalyzing the formation of norstatin scaffold in leuhistin

○Taku Mizutani1,2, Takayoshi Awakawa3, Ikuro Abe1,2 (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. CRIIM, The Univ. of Tokyo, 3. RIKEN CSRS)
2:10 PM - 2:22 PM JST(5:10 AM - 5:22 AM UTC)

[27-29-pm06]Structural basis for 3-amino-3-carboxypropyl transfer in nocardicin biosynthesis

Yaojie Gao1, Masayuki Karasawa2, ○Zhiyang Quan3, Takahiro Mori1, Masahiro Kanaida1, Craig A. Townsend4, Tohru Terada2, Ikuro Abe1, Takayoshi Awakawa3 (1. Grad. Sch. Pharm. Sci., UTokyo, 2. GSALS, UTokyo, 3. CSRS, RIKEN, 4. JHU Chem)
2:22 PM - 2:34 PM JST(5:22 AM - 5:34 AM UTC)

[27-29-pm07S]Exploration of the biosynthetic genes for the steroidal natural product formosterol integrating virtual screening and biosynthetic analysis

○Ryuki Wagatsuma1, Yuto Homma1, Yohei Morishita1, Taro Ozaki1, Teigo Asai1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)
2:34 PM - 2:46 PM JST(5:34 AM - 5:46 AM UTC)

[27-29-pm08S]Elucidation of the Reaction Mechanism for the Atypical Terpene Cyclase Forming a Vinigrol Scaffold and Engineering of Its Cyclization Pathway

○Ryo Matsuda1, Kento Tsukada1, Fumito Sato1, Taro Ozaki1, Yohei Morishita1, Sho Furumura1, Yuto Homma1, Hikaru Sekiya1, Akihiro Sugawara1, Teigo Asai1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)
2:46 PM - 2:58 PM JST(5:46 AM - 5:58 AM UTC)

[27-29-pm09S]Research on Improving Heterologous Production of Glycyrrhizin Using Aspergillus oryzae as Host

○Yukiho Hirabayashi1, Taro Ozaki1, Yohei Morishita1, Teigo Asai1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ.)
2:58 PM - 3:10 PM JST(5:58 AM - 6:10 AM UTC)

[27-29-pm10S]Investigation of the effects of fluorine group introduction position on diterpene cyclization reactions

○Hikaru Sekiya1, Taro Ozaki1, Akihiro Sugawara1,2, Yohei Morishita1, Teigo Asai1 (1. Grad. Sch. Pharm. Sci., Tohoku Univ., 2. Ōmura Inst. & Grad. Sch. Infect. Control Sci., Kitasato Univ.)
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