[28-27-pm] Drug discovery, structure-activity relationship 2 | The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[28-27-pm]Drug discovery, structure-activity relationship 2

Sat. Mar 28, 2026 3:30 PM - 5:30 PM JST
Sat. Mar 28, 2026 6:30 AM - 8:30 AM UTC

Room 27 (3101, Bldg. 3, Area 4 [1F])

Chair: Hiroaki Ishida, Mizuki Watanabe

3:30 PM - 3:42 PM JST(6:30 AM - 6:42 AM UTC)

[28-27-pm11S]Synthesis and evaluation of Dehydroevodiamine derivatives as G-quadruplex ligand

○Tomoki Oyamada¹, Yue Ma^1,2, Hiroyuki Kagechika¹ (1. LBB, Science Tokyo, 2. Res. Infra. Mgmt. Ctr., Science Tokyo)

3:42 PM - 3:54 PM JST(6:42 AM - 6:54 AM UTC)

[28-27-pm12S]Development of novel retinoids exhibiting selective CRABP1-mediated non-genomic activity

○ZHAOFENG HAUNG¹, Yue Ma^1,2, Michiko Nakaishi^1,2, Li-Na Wei³, Hiroyuki Kagechika¹ (1. LBB, Inst. Sci.Tokyo, 2. Res. Infra. Mgmt. Ctr., Inst. Sci. Tokyo, 3. Univ. Minnesota Med. School)

3:54 PM - 4:06 PM JST(6:54 AM - 7:06 AM UTC)

[28-27-pm13S]Development of Biomimetic boron encapsulated liposomes for BNCT via remote loading method and cell membrane coated strategy

○YUCHEN YUAN¹, Satoshi Okada², Hiroyuki Nakamura² (1. Sch. Life Sci. Tech., Inst. Sci. Tokyo, 2. Inst. Integr. Res., Inst. Sci. Tokyo)

4:06 PM - 4:18 PM JST(7:06 AM - 7:18 AM UTC)

[28-27-pm14S]Structural development of ghrelin receptor allosteric modulators as potential therapeutics for cancer cachexia

○Kotomi Sato¹, Fumika Karaki¹, Yuki Shiimura², Dohyun Im³, Kanako Miyano⁴, Yasuhito Uezono⁵, Hideaki Fujii¹ (1. Sch. Pharm., Kitasato Univ., 2. Inst. Life Sci., Kurume Univ., 3. Grad. Sch. Med., Kyoto Univ., 4. Fac. Pharm., Juntendo Univ., 5. The Jikei Univ. Sch. Med.)

4:18 PM - 4:30 PM JST(7:18 AM - 7:30 AM UTC)

[28-27-pm15S]Discovery of Novel DOI Derivatives for Functional Separation of Hallucinogenic and Antidepressant Activities: Synthesis and SAR Study.

○Reo Saito^1,2, Tomoya Sugai^1,2, Iroha Kondou³, Daisuke Ibi³, Noriki Kutsumura^1,2 (1. University of tsukuba, 2. IIIS, Univ. Tsukuba, 3. Pharm. Meijo Univ.)

4:30 PM - 4:42 PM JST(7:30 AM - 7:42 AM UTC)

[28-27-pm16S]Development of novel small-molecule bradykinin 2 receptor agonists via structure-based antagonist-to-agonist switching

○Emi Ikeda^1,2, Arisa Shinkai^1,2, Yuzhong Gu³, Kazuhiro Kobayashi^3,4, Kouki Kawakami^3,4, Hideaki Kato^3,4, Tsuyoshi Saitoh^2,5 (1. Grad. Sch. Sci. Tech., Univ. Tsukuba, 2. WPI-IIIS, Univ. Tsukuba, 3. Grad. Sch. Sci., Univa. Tokyo, 4. RCAST, Univ. Tokyo, 5. Grad. Comp. Hum. Sci., Univ. Tsukuba)

4:42 PM - 4:54 PM JST(7:42 AM - 7:54 AM UTC)

[28-27-pm17S]Development of antiausterity naringenin derivatives

○Ryuto Hotei¹, Akira Takagi¹, Kensuke Okuda¹ (1. Kobe Pharm. Univ.)

4:54 PM - 5:06 PM JST(7:54 AM - 8:06 AM UTC)

[28-27-pm18S]Structure-Activity Relationship of antiausterity agent Callistrilone O

○Kokoa Taniguchi¹, Kensuke Nishi¹, Akira Takagi¹, Kensuke Okuda¹ (1. Kobe Pharm. Univ.)

5:06 PM - 5:18 PM JST(8:06 AM - 8:18 AM UTC)

[28-27-pm19S]Structure-Activity Relationship Study of MR1 Ligand Ac-6-FP Regulating MAIT Cells

○Sumika Yamada^1,2, Naoki Obiya¹, Toshiki Fujii¹, Norihito Arichi¹, Hiroaki Ohno¹, Shinsuke Inuki^1,2,3 (1. Grad. Sch. Pharm. Sci., Kyoto Univ., 2. Grad. Sch. Biomed. Sci., Tokushima Univ., 3. IPHF, Tokushima Univ.)

5:18 PM - 5:30 PM JST(8:18 AM - 8:30 AM UTC)

[28-27-pm20S]Development of anticancer prodrugs targeting biomarker enzyme activities for the treatment of ovarian cancer peritoneal metastasis

○Seiryo Murakami¹, Kyohhei Fujita², Yasuteru Urano^2,3 (1. Fac. Pharm. Sci., Tokyo Univ., 2. Grad. Sch. Med., Tokyo Univ., 3. Grad. Sch. Pharm. Sci., Tokyo Univ.)

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