The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

Organizer: Hinata Osawa (Grad. Sch. Med. Dent. Pharm. Sci., Okayama Univ.), Yoshino Akizuki (Grad. Sch. Pharmaceut. Sci., Hoshi Univ.)

Targeted protein degradation technologies are attracting increasing attention as a novel drug discovery strategy that can act on proteins that have been difficult to target with conventional inhibitors. In particular, technologies such as PROTACs (PROteolysis TArgeting Chimeras) and degradation tags have advanced rapidly, showing interdisciplinary expansion encompassing compound design and synthesis, evaluation of degradation activity, mechanism-of-action studies, and even the optimization of molecular design through computational science.
This symposium will feature graduate students at the forefront of such research, who will present their latest findings obtained through diverse approaches ranging from degrader development to mechanistic and theoretical studies. By fostering active discussions among young researchers with different areas of expertise, we aim to generate new ideas and collaborations that will contribute to the development of next-generation degradation technologies and pharmaceutical innovation. We hope that this symposium will serve as a vibrant forum for active exchange among researchers across generations and disciplines, and as a catalyst for creating new currents in future drug discovery research.