[29-28-pm] Drug design 1 and Modalities, biomolecules, biologics 2 | The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

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Session Details

Oral Presentation(A) Pharmaceutical Chemistry

[29-28-pm]Drug design 1 and Modalities, biomolecules, biologics 2

Sun. Mar 29, 2026 1:10 PM - 3:10 PM JST
Sun. Mar 29, 2026 4:10 AM - 6:10 AM UTC

Room 28 (3201, Bldg. 3, Area 4 [2F])

Chair: Hiroki Kakuta, Makoto Yoritate

1:10 PM - 1:22 PM JST(4:10 AM - 4:22 AM UTC)

[29-28-pm01]Discovery of gapmer-type antisense oligonucleotides for personalized N-of-1 medicine

○Yuuya Kasahara^1,2,3, Harumi Yamaguma¹, Natsumi Kameoka¹, Misaki Ono², Takashi Ishii², Tojo Nakayama², Kotaro Yoshioka², Hiroya Kuwahara², Kumiko Ui-Tei², Satoshi Obika^3,4, Takanori Yokota² (1. NIBN, 2. TIDE Center, Science Tokyo, 3. Grad. Sch. Pharm. Sci., UOsaka, 4. OTRI, UOsaka)

1:22 PM - 1:34 PM JST(4:22 AM - 4:34 AM UTC)

[29-28-pm02]Screening of 2’-modified nucleoside applicable to enzymatic oligonucleotide synthesis

○Kenta Ishida^1,2, Hidekazu Hoshino^1,2, Satoshi Obika^2,3, Yuuya Kasahara^1,2 (1. NIBN, 2. Grad. Sch. Pharm. Sci., UOsaka, 3. OTRI, UOsaka)

1:34 PM - 1:46 PM JST(4:34 AM - 4:46 AM UTC)

[29-28-pm03]Development of the polymerase mutants for bridged nucleic acids with functional groups and in vitro selection

○Hidekazu Hoshino^1,2, Kenta Ishida^1,2, Takumi Okuda¹, Satoshi Obika^2,3, Yuuya Kasahara^1,2 (1. NIBN, 2. Grad. Sch. Pharm. Sci., UOsaka, 3. OTRI, UOsaka)

1:46 PM - 1:58 PM JST(4:46 AM - 4:58 AM UTC)

[29-28-pm04]Synthesis of the Artificial Nucleic Acid 2-Oxa-5-Thia-Bicyclo[2.2.2]Octylthymine and Its Introduction into Oligonucleotides

○Tetsuya Kodama^1,2, Miyu Ito¹, Matsumoto Suguru¹, Natsuki Yokota¹, Hidekazu Hiroaki^1,2 (1. Grad. Sch. Pharm. Sci., Nagoya Univ., 2. COMIT)

1:58 PM - 2:10 PM JST(4:58 AM - 5:10 AM UTC)

[29-28-pm05]RNAi effects of lipid-siRNA incorporating chemically modified nucleic acids (CM-lipid-siRNAs)

○Takanori Kubo¹, Rina Tansou¹, Shizuka Kurosawa², Makoto Makino², Miki Ohno², Yoshitaka Taniguchi², Kazuyoshi Yanagihara^1,3 (1. Fac. Pharm., Yasuda Women's Univ., 2. Toray Res. Ctr., 3. Natl. Cancer Ctr.)

2:10 PM - 2:22 PM JST(5:10 AM - 5:22 AM UTC)

[29-28-pm06][Skipped Number]

2:22 PM - 2:34 PM JST(5:22 AM - 5:34 AM UTC)

[29-28-pm07]Development of Selenium-Incorporated Indole based-theranostics system

○Neha Jain¹, Michio Iwoaka¹ (1. Institute of Advanced Biosciences, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa 259-1292, Japan)

2:34 PM - 2:46 PM JST(5:34 AM - 5:46 AM UTC)

[29-28-pm08]Evaluation of Novel 18 kDa TSPO Ligands as Specific PET Imaging Markers for neuroinflammation

○ANJANI KUMAR TIWARI¹, Priya Singh¹ (1. Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India-226025)

2:46 PM - 2:58 PM JST(5:46 AM - 5:58 AM UTC)

[29-28-pm09]Evaluation of the BNCT activity of bis(boron) macrocyclic polyamine derivatives

○HIROKI UEDA¹, WAKANA YOSHIDA¹, TOSHIFUMI TOJO¹, TOMOHIRO TANAKA², MINORU SUZUKI³, YOSHINORI SAKURAI³, SHIN AOKI^1,4 (1. Fac. Pharm. Sci., Tokyo Univ. Sci., 2. Fac. Pharm. Sci., Okayama Univ., 3. Inst. Integr. Radiat. & Nucl. Sci., Kyoto Univ., 4. Res. Inst. Sci. & Technol., Tokyo Univ. Sci.)

2:58 PM - 3:10 PM JST(5:58 AM - 6:10 AM UTC)

[29-28-pm10]Combination effects of semi-synthetic macrolide OMT derivative and SPR741 against Gram-negative bacteria

○Taichi Kamo¹, Aoi Kimishima¹, Hiroshi Hamamoto², Hidehito Matsui¹, Sota Homma¹, Yukiko Ujie¹, Hideaki Hanaki¹, Toshiaki Sunazuka¹, Yukihiro Asami¹ (1. Ōmura Inst., Kitasato Univ., 2. Fac. Med., Yamagata Univ.)

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