講演情報
[22a-D901-8]Direct Discrimination of Bio-Molecules in Mixture by Single-Molecule Measurement
〇(D)Jiho Ryu1, Yuki Komoto1, Takahito Ohshiro1, Masateru Taniguchi1 (1.Osaka Univ.)
キーワード：
Single-molecule measurement、Nano-gap、Machine learning
Single-molecule measurement is a method of measuring the current of a molecule using nano-gap electrode. Recent studies have shown active research in analyzing the current characteristics of single-molecules for their identification/classification. However, conventional methods for-identy training based on measurements of target molecules, limiting their application to samples that require a large number of measurement and are difficult to isolate. In this study, we developed a method to identify molecules from single to determine the mix machine learning. Compared to the existing method, our new method discriminated between dGMP and dTMP with higher accuracy.This result expands the applicability of single-molecule measurement to samples that are difficult to purify.