セッション詳細
[NFS-03]Neuroscience Frontier Symposium 03 Basic Science of alpha-Synuclein
2025年5月23日(金) 8:00 〜 10:00
第07会場(大阪国際会議場12F 特別会議場)
座長:Stella M. Papa(Emory University, USA), 髙橋 良輔(京都大学総合研究推進本部)
Alpha-synuclein (aSyn) is considered a culprit for Parkinson's disease (PD). The physiological and pathological functions of aSyn, however, remain largely unclear. In this symposium, world experts and rising stars in this field will discuss the role of aSyn in PD based on current research results.
[NFS-03-1]Research priorities to understand the role of alpha-Synuclein in Parkinson's disease
Stella M. Papa (Emory University)
Stella M. Papa, M.D. is a Professor at the Department of Neurology, Emory University School of Medicine, and Core Scientist at Emory National Primate Research Center. She completed her studies in Medicine (M.D.) at National University of Buenos Aires, Argentina, and her post-doctoral trainings at University of Navarra, Spain, and NINDS, National Institutes of Health, Bethesda, Maryland, USA. Dr. Papa leads a research team dedicated to experimental therapeutics for Parkinson’s disease (PD) and Movement Disorders. Her research for PD is focused on improving the sensorimotor network function through the regulation of striatal circuits, as well as halting the progression of neurodegeneration through targeting disease mechanisms. Dr. Papa’s laboratory uses genetic, electro-physiological, and pharmacological strategies to manipulate mechanisms in vivo with temporal precision and cellular resolution. She uses rodents and primates to model PD pathology for studies for disease-modifying therapies. Her work is based on multidisciplinary projects with collaborations worldwide, such as Stanford University (US), Osaka University (Japan), Universita Cattolica del Sacro Cuore (Italy). Dr. Papa chairs the Emory University Research Committee for Biological and Health Sciences. Dr. Papa has served in multiple national and international scientific review panels and contributed to various scientific societies chairing committees and panel of experts.
[NFS-03-2]Molecular mechanisms of Parkinson's disease: from classification to treatment
Tiago F. Outeiro1,2 (1.University Medical Center Goettingen, 2.Newcastle University)
Prof. Tiago Outeiro graduated in Biochemistry at the University of Porto and was an Erasmus student at the University of Leeds in the UK. Prof. Outeiro did his PhD thesis at the Whitehead Institute for Biomedical research - MIT. He was then a Postdoctoral Research Fellow in the Department of Neurology of the Massachusetts General Hospital - Harvard Medical School where he focused on the study of Neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease. Prof. Outeiro directed the Cell and Molecular Neuroscience Unit at IMM, Lisbon, from 2007 to 2014, and is currently Full Professor and the Director of the Department of Experimental Neurodegeneration at the University Medical Center Goettingen, in Germany. Prof. Outeiro holds a joint Professor position at Newcastle University in the UK, and is an invited Professor at the University of the Algarve. Prof. Outeiro has authored >360 research articles in international journals and participates in various international boards and in collaborative projects with the aim of identifying the molecular basis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. He has been awarded multiple prizes and grants in Portugal, Germany, from the European Union, and from other international funding agencies.
[NFS-03-3]αシヌクレイノパチーの生物学的バイオマーカー確立を目指して
奥住 文美, 波田野 琢, 服部 信孝 (順天堂大学医学部附属順天堂医院 脳神経内科)
2009 Juntendo University School of Medicine
2014- Graduate student, Juntendo University Graduate School of
Medicine
2018- Assistant Professor, Dept. of Neurology, Juntendo University
2019- Research Fellow, Doshisha University, Graduate School of
Brain Science
2021- Assistant Professor, Dept. of Neurology, Juntendo University
2022- Associate Professor, Dept. of Neurology, Juntendo University
I am working on the development of biomarkers for synucleinopathy
and studying the aggregation and propagation of alpha-synuclein.
2014- Graduate student, Juntendo University Graduate School of
Medicine
2018- Assistant Professor, Dept. of Neurology, Juntendo University
2019- Research Fellow, Doshisha University, Graduate School of
Brain Science
2021- Assistant Professor, Dept. of Neurology, Juntendo University
2022- Associate Professor, Dept. of Neurology, Juntendo University
I am working on the development of biomarkers for synucleinopathy
and studying the aggregation and propagation of alpha-synuclein.
[NFS-03-4]剖検脳を対象にしたシングルセル解析によるαシヌクレイノパチーの病態解明
小河 浩太郎 (大阪大学大学院医学系研究科 神経内科学)
Kotaro Ogawa is a neurologist specializing in genomic biology. He received his medical degree from Osaka University in 2011. After four years of experience in internal medicine and neurological treatment, he started PhD training with Prof. Hideki Mochizuki at Osaka University. In 2020, he received a Ph.D. degree in medicine. In 2021, he became a project assistant professor in the Department of Neurology at Osaka University. In 2022, he was appointed assistant professor in the Department of Neurology at Osaka University. He specializes in genomic and transcriptomic analysis of multifactorial genetic disorders in the brain and nervous system and is involved in multi-omics analysis of neurodegenerative diseases such as Parkinson's disease and multiple system atrophy.