セッション詳細
[S-01]シンポジウム01 Understanding Aging and Neuromuscular Disease from the Perspective of Disruption of the Autophagy-Lysosomal Pathway
2025年5月21日(水) 9:50 〜 11:50
第04会場(大阪国際会議場10F 会議室1001-1002)
座長：島田 斉（新潟大学脳研究所 統合脳機能研究センター臨床機能脳神経学分野）, 池中 建介（大阪大学医学部 神経内科医局）
The autophagy-lysosome pathway is crucial for body-wide homeostasis, including the brain. Its functionality declines with aging and is impaired early in various neuromuscular diseases. Understanding, monitoring, and intervening in this pathway holds promise for new diagnostic and therapeutic strategies. This symposium will provide an overview of the latest findings on the autophagy-lysosome pathway, from basic science to clinical research. Topics include its role in neuromuscular disease onset, therapeutic targeting, and imaging biomarkers. The first three presenters will discuss molecular mechanisms and dysfunctions in aging and disease; the next three will cover muscle and neurodegenerative diseases, and PET imaging. We hope the learnings from this symposium will pave the way for new approaches to overcoming neuromuscular diseases in our aging society.
[S-01-1]オートファジー：疾患と老化に対抗する細胞の守護者
吉森 保 (大阪大学大学院医学系研究科)
Tamotsu Yoshimori’s biography
Prof. Tamotsu Yoshimori was graduated from Osaka University and received his PhD degree in Medical Science from the University. After working at several places including European Molecular Biology Laboratory and National Institute of Basic Biology (Prof Yoshinori Ohsumi’s lab), he became a professor at Graduate School of Frontier Biosciences / Medicine, Osaka University in 2010. He acted as the dean of Graduate School of Frontier Biosciences, Osaka University in 2018-2022. He is now a professor emeritus of Osaka University and a specially appointed professor in Graduate School of Medicine, Osaka University. He is an editor of Journal Cell Science, and on the editorial board of Journal of Cell Biology, and so on. He was a president of Japan Society for Cell Biology in 2016-2018. He was awarded many prizes including Medal with Purple Ribbon in 2019 by Japanese Government and Highly Cited Researchers 6 times by Clarivate Analytics.
Prof. Tamotsu Yoshimori was graduated from Osaka University and received his PhD degree in Medical Science from the University. After working at several places including European Molecular Biology Laboratory and National Institute of Basic Biology (Prof Yoshinori Ohsumi’s lab), he became a professor at Graduate School of Frontier Biosciences / Medicine, Osaka University in 2010. He acted as the dean of Graduate School of Frontier Biosciences, Osaka University in 2018-2022. He is now a professor emeritus of Osaka University and a specially appointed professor in Graduate School of Medicine, Osaka University. He is an editor of Journal Cell Science, and on the editorial board of Journal of Cell Biology, and so on. He was a president of Japan Society for Cell Biology in 2016-2018. He was awarded many prizes including Medal with Purple Ribbon in 2019 by Japanese Government and Highly Cited Researchers 6 times by Clarivate Analytics.
[S-01-2]オートファジーによるリソソーム恒常性の維持とその老化・疾患における役割
中村 修平 (奈良県立医科大学 医学部医学科 生化学講座)
2008: Ph.D., Graduate School of Science, Hokkaido University, Japan (Prof. Minoru Tanaka lab.)
2008-2011: Postdoc, Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Japan (Prof. Minoru Tanaka lab.)
2011-2016: Postdoctoral research fellow, Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Germany (Prof. Adam Antebi lab.)
2016-2018: Assistant Professor, Department of Genetics, Graduate School of Medicine, Osaka University, Japan (Prof. Tamotsu Yoshimori lab.)
2018-2023: Associate Professor, Institute for Advanced Co-Creation Studies, Osaka University, Japan (Prof. Tamotsu Yoshimori lab.)
2023-present: Professor, Department of Biochemistry, School of Medicine, Nara Medical University
2008-2011: Postdoc, Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Japan (Prof. Minoru Tanaka lab.)
2011-2016: Postdoctoral research fellow, Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Germany (Prof. Adam Antebi lab.)
2016-2018: Assistant Professor, Department of Genetics, Graduate School of Medicine, Osaka University, Japan (Prof. Tamotsu Yoshimori lab.)
2018-2023: Associate Professor, Institute for Advanced Co-Creation Studies, Osaka University, Japan (Prof. Tamotsu Yoshimori lab.)
2023-present: Professor, Department of Biochemistry, School of Medicine, Nara Medical University
[S-01-3]神経炎症におけるアストロサイトmitophagyの役割
門脇 淳 (大阪大学大学院医学系研究科 神経内科学講座)
Curriculum Vitae
Education :
2017 Ph.D. Department of Neurology, Graduate School of Medicine, Osaka University
2005 M.D. Osaka University School of Medicine
Work Experience :
2023 - Department of Neurology, Graduate School of Medicine, Osaka University
(2024 - Specially Appointed Associate Professor, 2023 - 2024 Assistant Professor, 2023 Specially Appointed Assistant Professor)
2018 - 2022 Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA (Research Fellow)
2016 - 2017 Higashi Osaka Medical Center, Osaka
2010 -2016 Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
(2014 -2016 Research Fellow , 2010-2014 Research Volunteer)
2009 - 2010 Osaka University Hospital, 2007 - 2009 Higashi Osaka Medical Center (Senior resident)
2006 -2007 Osaka University Hospital, 2005 -2006 NTT WEST Osaka Hospital (Junior resident)
Education :
2017 Ph.D. Department of Neurology, Graduate School of Medicine, Osaka University
2005 M.D. Osaka University School of Medicine
Work Experience :
2023 - Department of Neurology, Graduate School of Medicine, Osaka University
(2024 - Specially Appointed Associate Professor, 2023 - 2024 Assistant Professor, 2023 Specially Appointed Assistant Professor)
2018 - 2022 Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA (Research Fellow)
2016 - 2017 Higashi Osaka Medical Center, Osaka
2010 -2016 Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
(2014 -2016 Research Fellow , 2010-2014 Research Volunteer)
2009 - 2010 Osaka University Hospital, 2007 - 2009 Higashi Osaka Medical Center (Senior resident)
2006 -2007 Osaka University Hospital, 2005 -2006 NTT WEST Osaka Hospital (Junior resident)
[S-01-4]筋疾患におけるオートファジー・リソソーム経路の機能不全
江浦 信之, 杉江 和馬 (奈良県立医科大学 脳神経内科学)
Nobuyuki Eura is a clinical neurologist and myologist in the Department of Neurology at Nara Medical University. He graduated from Nara Medical University School of Medicine in 2008 and completed his neurology residency at Nara Medical University Hospital. Following his residency, he pursued studies in muscle pathology and neuroembryology, earning a Ph.D. in 2020 with groundbreaking work on a novel method for generating brainstem organoids. From April 2021 to March 2023, he undertook a postdoctoral fellowship in Dr. Ichizo Nishino’s lab at the National Center of Neurology and Psychiatry, focusing on the diagnosis and molecular pathomechanisms of oculopharyngodistal myopathy. He is currently engaged in clinical myology, with a focus on muscle pathology and genetics.
[S-01-5]神経変性疾患におけるオートファジー-リソソーム経路障害
角田 渓太, 池中 建介, 望月 秀樹 (大阪大学大学院医学系研究科 神経内科)
Dr. Keita Kakuda is an Assistant Professor at Osaka University's Department of Neurology and a neurologist specializing in Parkinson's disease and movement disorders. He earned both his MD (2013) and PhD (2019) from Osaka University, completing his doctoral research under Prof. Hideki Mochizuki. He began his career as a resident and clinical fellow at Higashiosaka City General Hospital, followed by a fellowship in neuro-rehabilitation at Morinomiya Hospital. He later served as Chief Physician at Higashiosaka City General Hospital before assuming his current role in 2021. His research focuses on the propagation mechanisms of α-synuclein aggregates, particularly their interactions with lipids and the role of lysosomal aging in neurodegenerative diseases.
[S-01-6]リソソーム機能不全を標的とするイメージング技術の開発
島田 斉1,2 (1.新潟大学脳研究所 統合脳機能研究センター臨床機能脳神経学分野, 2.量子科学技術研究開発機構 量子医科学研究所 脳機能イメージング研究センター)
Dr. Shimada obtained M.D. from Chiba University in 2003 and trained in Neurology at Chiba University Hospital and affiliated hospitals. He received Ph.D. degree in Advanced Life Science from Chiba University, Japan, in 2009. He was a postdoctoral researcher from April 2009, a researcher from December 2009, senior researcher from July 2014, and the principal researcher from July 2017 at the Department of Functional Brain Imaging Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan. He has transferred to the Center for integrated human brain science (CIHBS) of Niigata University as a professor as of April, 2021. He also became CIHBS center director in April 2024. His current research interests include Molecular Neuroimaging in neurodegenerative disorders, physiological background of psychiatric symptoms, mechanisms for maintaining homeostasis in the brain environment and its disruption.