Session Details

Genetic and developmental bases for mammalian neocortical evolution

Sat. Jun 22, 2024 1:00 PM - 3:30 PM JST
Sat. Jun 22, 2024 4:00 AM - 6:30 AM UTC
Room D(Miyako Messe(B1F)/Special Exhibition Hall(B))
Chairpersons:Tadashi Nomura(KIT), Chiaki Maruyama(TMIMS)
The mammalian neocortex is a unique neuroanatomical structure characterized by tangential surface expansion and six layers. Neocortical expansion is accelerated in primates and humans and is thought to contribute to the evolution of human-specific cognitive functions. However, the cellular and molecular mechanisms underlying the evolution of the neocortex remain to be elucidated. This symposium will focus on the diverse developmental mechanisms predicted to have contributed to the evolution of the mammalian neocortex. Selected speakers will present recent findings on species-specific characteristics of neural progenitors, unique cellular and molecular properties of layer-specific neurons, and human-specific genetic bases that contributed to neocortical expansion. Lively discussions with the audience are expected to enhance our understanding of the developmental basis for the evolution of the mammalian neocortex.
Co-organized by:Development Growth & Differentiation(DGD)

[S07-01]Conserved developmental mechanisms for the interhemispheric connection preceded the evolution of mammalian corpus callosum半球間結合における保存された発生メカニズムは哺乳類脳梁の進化に先行した

*Tadashi Nomura1, Ryota Noji2 (1. Applied Biology, Kyoto Institute of Technology, 2. Developmental Neurobiology, Kyoto Prefectural University of Medicine)
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[S07-02]Molecular and evolutionary mechanisms of sensory input neuron specification in the developing brain大脳における感覚入力ニューロンの分化プログラムの制御と進化

*Carina Hanashima1 (1. Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University)
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[S07-03]Extra-environmental factors and brain development

*Jun Hatakeyama1, Saya Okada1, Haruka Sato1, Kenji Shimamura1 (1. IMEG, Kumamoto University)
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[S07-04]Molecular mechanisms underlying the subplate layer expansion during brain evolution

*Chiaki Ohtaka-Maruyama1 (1. Developmental Neuroscience Project, Tokyo Metropolitan Institute of Medical Science)
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[S07-05]Building our brains: From RNA to evolution

*Debra Silver1 (1. Duke University)
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[S07-06]An evolutionary new allele of human-specific gene NOTCH2NLB that enhances cortical neurogenesis is positively selected in the modern human population

*Ikuo K Suzuki1 (1. The University of Tokyo)
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