Session Details
[S04]Symposium 04 Inheriting genomes through the transgenerational maze
Wed. Jun 10, 2026 9:15 AM - 12:15 PM JST
Wed. Jun 10, 2026 12:15 AM - 3:15 AM UTC
Wed. Jun 10, 2026 12:15 AM - 3:15 AM UTC
Room A = Mediam Hall (2F)(JMS ASTERPLAZA 2F)
Chairpersons:Shosei Yoshida(NIBB), Tomoya Kitajima(RIKEN BDR)
Co-organized by：Grant-in-Aid for Transformative Research Areas (A) "Dynamic Reproductive Lifespan" and AMED-ASPIRE "Germ Cell Dynamics and Transgenerational Health Risks"
Life continues across generations by transmitting genomes through germ cells. Yet inheritance is never perfectly faithful. Genomes change at multiple scales, from point mutations to chromosome-level rearrangements and karyotype variation (aneuploidy), and these changes can emerge as somatic phenotypes in subsequent generations. Sometimes they cause disease; sometimes they fuel evolution. In some organisms, genome alterations are developmentally programmed and woven into the life cycle. In this symposium, we explore how diverse organisms, from protozoans to plants and humans, navigate this maze-balancing genome stability with plasticity-and still succeed in carrying life forward.
Life continues across generations by transmitting genomes through germ cells. Yet inheritance is never perfectly faithful. Genomes change at multiple scales, from point mutations to chromosome-level rearrangements and karyotype variation (aneuploidy), and these changes can emerge as somatic phenotypes in subsequent generations. Sometimes they cause disease; sometimes they fuel evolution. In some organisms, genome alterations are developmentally programmed and woven into the life cycle. In this symposium, we explore how diverse organisms, from protozoans to plants and humans, navigate this maze-balancing genome stability with plasticity-and still succeed in carrying life forward.
Opening remark
[S04-01]Integrating Genetic and Epigenetic Information During Somatic Genome Development in Tetrahymena
*Kazufumi Mochizuki1 (1. Institute of Human Genetics (IGH), CNR)
[S04-02]Programmed DNA Elimination in the Nematode Caenorhabditis auriculariae
*Asako Sugimoto1 (1. Graduate School of Life Sciences, Tohoku University)
[S04-03]Somatic mutation dynamics in long-lived trees
*Akiko Satake1 (1. Department of Biology, Faculty of Science, Kyushu University)
[S04-04]Understanding and preventing age-associated chromosome segregation errors in oocytes老化卵子における染色体分配エラーの理解と抑止
*Tomoya Kitajima1 (1. RIKEN Center for Biosystems Dynamics Research)
[S04-05]Spermatogonial stem cells shape the origin and transmission of de novo mutations新規突然変異の生成と伝達を担う精子幹細胞
*Shosei Yoshida1 (1. Division of Germ Cell Biology, National Institute for Basic Biology)
[S04-06]Long-Term Serial Passage Reveals Transgenerational Effects of Somatic and Germline Mutations長期間の継代実験から明らかになった、世代を超えて及ぶ体細胞変異および生殖細胞系列変異の影響
*Arikuni Uchimura1, Yasunari Satoh1, Masaaki Toshishige1, Mayumi Higuchi2, Sayaka Wakayama3, Teruhiko Wakayama3, Takeshi Yagi2 (1. Department of Molecular Biosciences, Radiation Effects Research Foundation, 2. Graduate School of Frontier Biosciences, The University of Osaka, 3. Advanced Biotechnology Center, University of Yamanashi)
[S04-07]From somatic exposure to germline inheritance: unresolved impacts of environmental and therapeutic mutagens
*Raheleh Rahbari1 (1. Wellcome Sanger Institute)