[3406-09] F. 創薬（原虫（１））

1:36 PM - 1:48 PM JST(4:36 AM - 4:48 AM UTC)

[3406-09-04] Antimalarial activity of 2-heptyl-4-hydroxyquinoline (HHQ) targeting Qo and Qi sites of bc₁ complex in mitochondria electron transport chain.

Normalita Eka Pravitasari^1,2, ○Takaya Sakura^1,3,4, Kibet Ng’etich Japheth^5,6, Jun Takouda⁷, Shusaku Mizukami⁸, Kenji Hirayama^1,9, Kohsuke Takeda ⁷, Yoshimasa Tanaka¹⁰, Kiyoshi Kita^1,4,11, Daniel Ken Inaoka^1,3,4,11 (1. School of Tropical Medicine and Global Health, Nagasaki Univ., 2. Struct Mol and Regener Med, Eijkman Res Center for Mol Biol Nat Res and Innov, 3. Mol. Infe. Dynamics Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 4. Infe. BioChem. Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 5. Mol. Microbiol. Immunol. Dept., Grad School of Biomed. Sci., Nagasaki Univ., 6. Center for Trad Med and Drug Res, Kenya Med Res Inst, 7. Cell Reg. Dept., Grad School of Biomed. Sci., Nagasaki Univ., 8. Immune Reg. Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 9. Immunogenetics Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 10. Center for Medical Innovation, Nagasaki Univ., 11. Biomed. Chem. Dept., Grad. School Med., The University of Tokyo)

Keywords:

マラリア,創薬,天然物,呼吸鎖

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