Session Details
[3406-09]F. 創薬（原虫（１））
Wed. Mar 19, 2025 1:00 PM - 1:48 PM JST
Wed. Mar 19, 2025 4:00 AM - 4:48 AM UTC
Wed. Mar 19, 2025 4:00 AM - 4:48 AM UTC
Room D(1F)
Chair:Yoshifumi Nishikawa
[3406-09-01]Molecular docking approach using AlphaFold-predicted protein structures to accelerate antimalarial drug discovery
○Ng'etich Japheth Kibet1,2,3, Normalita Eka Pravitasari4,5, Takeshi Ishikawa6, Ayato Sato7, Shinjiro Hamano8, Noriyuki Nishida1, Takaya Sakura4,9,10, Daniel Ken Inaoka4,9,10,11 (1. Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 2. Program for Nurturing Global Leaders in Tropical and Emerging Communicable Disease, Graduate School of Biomedical Science, Nagasaki University., 3. Center for Traditional Medicine and Drug Research, Kenya Medical Research Institute, Kenya., 4. School of Tropical Medicine and Global Health, Nagasaki University, 5. Structural Molecular, and Regenerative Medicine, Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Indonesia. , 6. Department of Chemistry, Biotechnology, and Chemical Engineering, Graduate School of Science and Engineering, Kagoshima Institute. , 7. Institute of Transformative Biomolecules (ITbM), Nagoya University, 8. Department of Parasitology, Institute of Tropical Medicine (NEKKEN) Nagasaki University., 9. Department of Molecular Infection Dynamics, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine (NEKKEN), Nagasaki University., 10. Department of Infection Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University., 11. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.)
[3406-09-02]A novel compound X exerts asexual antimalarial activity by targeting Plasmodium falciparum plasmepsin X
○Jing Jing Hong1, Naoya Asada2, Rina Kaki2, Kenji Takaya2, Takaya Sakura1,3,4, Ryuta Ishii2, Kiyoshi Kita3,4,5, Teruhisa Kato2, Kenichi Matsumura2, Daniel Ken Inaoka1,3,4,5 (1. Department of Molecular Infection Dynamics, Institute of Tropical Medicine, Nagasaki University, 2. SHIONOGI & Co., Ltd, 3. School of Tropical Medicine and Global Health, Nagasaki University, 4. Department of Infection Biochemistry, Institute of Tropical Medicine, Nagasaki University, 5. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo)
[3406-09-03]Screening of novel terpenoid compounds for antimalarial activity and RNA-seq analysis in Plasmodium falciparum after compounds exposure.
○Kaito Sanae1, Makoto Hirai1, Teigo Asai2, Toshihiro Mita1 (1. Dept. of Tropical Med. and Parasitol., Fac. of Med., Juntendo Univ., 2. Grad Sch. of Pharm Sci., Tohoku Univ.)
[3406-09-04]Antimalarial activity of 2-heptyl-4-hydroxyquinoline (HHQ) targeting Qo and Qi sites of bc1 complex in mitochondria electron transport chain.
Normalita Eka Pravitasari1,2, ○Takaya Sakura1,3,4, Kibet Ng’etich Japheth5,6, Jun Takouda7, Shusaku Mizukami8, Kenji Hirayama1,9, Kohsuke Takeda 7, Yoshimasa Tanaka10, Kiyoshi Kita1,4,11, Daniel Ken Inaoka1,3,4,11 (1. School of Tropical Medicine and Global Health, Nagasaki Univ., 2. Struct Mol and Regener Med, Eijkman Res Center for Mol Biol Nat Res and Innov, 3. Mol. Infe. Dynamics Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 4. Infe. BioChem. Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 5. Mol. Microbiol. Immunol. Dept., Grad School of Biomed. Sci., Nagasaki Univ., 6. Center for Trad Med and Drug Res, Kenya Med Res Inst, 7. Cell Reg. Dept., Grad School of Biomed. Sci., Nagasaki Univ., 8. Immune Reg. Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 9. Immunogenetics Dept., Institute of Tropical Medicine (NEKKEN), Nagasaki Univ., 10. Center for Medical Innovation, Nagasaki Univ., 11. Biomed. Chem. Dept., Grad. School Med., The University of Tokyo)