The 146th Annual Meeting of the Pharmaceutical Society of Japan (Osaka)

Organizer: Ayako Furuhama (NIHS), Atsushi Ono (Okayama Univ.)

In recent years, the implementation of in silico methodologies in risk assessment has been progressing. For example, the Food Safety Commission of Japan (FSCJ) has been accumulating scientific knowledge, including comparative and validation data based on toxicity test data, to utilize in silico methodologies such as (quantitative) structure-activity relationship (Q)SAR and new approach methodologies (NAMs) in food health risk assessment. In 2021, the FSCJ published the "Guideline for Assessing Mutagenicity Using (Q)SAR in Risk Assessment" which was a standard implementation procedure for utilizing (Q)SAR prediction results in food health risk assessment. Furthermore, a grant from the FSCJ (Research Program for Risk Assessment Study on Food Safety, No JPCAFSC20242401, FY2024-2025) titled "Implementation of Mutagenicity Assessments Based on the OECD (Q)SAR Assessment Framework (QAF) for Risk Assessment" has been exploring the application of the OECD QAF to this guideline.
This symposium will present the results of the Research Program for Risk Assessment Study on Food Safety and introduce efforts to apply in silico methodologies and NAMs to the assessment for regulation of chemical substances in Japan. Additionally, we will provide an overview of the latest trends in international in silico assessment and considerations for its use in regulations.