Session Details

[GS02☆]Toxicity Assessment of Chemical Exposures on Subsequent Generations: Perspectives for Developing Predictive and Preventive Strategies

Sun. Mar 29, 2026 9:30 AM - 11:30 AM JST
Sun. Mar 29, 2026 12:30 AM - 2:30 AM UTC
Room 08 (A501, Bldg. 1, Area 2 [5F])
Organizer: Momoe Serizawa (Grad. Sch. Pharm. Sci., Uosaka), Mimo Hashizume (Yokohama Univ. of Pharmacy, Grad. Sch. Pharmaceut. Sci.)
In modern society, a wide range of chemical substances—including pharmaceuticals, food additives, pesticides, and environmental pollutants—are present in daily life, making it impossible to completely avoid exposure. In particular, exposure during pregnancy and developmental stages has been associated with adverse outcomes such as miscarriage, preterm birth, and growth retardation in the offspring. Recent studies have also suggested that parental exposure prior to conception may affect subsequent generations through epigenetic modifications.
To predict and mitigate such transgenerational health effects, it is essential to evaluate reproductive and developmental toxicity and to elucidate their underlying mechanisms. This symposium will present the latest research on reproductive and developmental toxicity conducted by graduate students, with the aim of advancing our understanding of the effects of chemical exposure. It is anticipated that this symposium will serve as a platform for active exchange of ideas among young researchers who will lead the future of this field, thereby contributing to its further development.

オーガナイザー挨拶

[GS02-1]Effects of pharmaceuticals on placental cell differentiation for advancing understanding of reproductive and developmental toxicity

○Momoe Serizawa1,2, Kazuma Higashisaka1,2,3, Wakako Okuno2, Juri Tsuda2, Yuya Haga1,2, Yasuo Tsutsumi1,2,4,5,6,7 (1. Grad. Sch. Pharm. Sci., UOsaka., 2. Sch. Pharm. Sci., UOsaka., 3. IACS., UOsaka., 4. Grad. Sch. Med., UOsaka., 5. MEI Ctr., UOsaka., 6. OTRI., UOsaka., 7. INSD., UOsaka.)

[GS02-2]Maternal exposure to TCDD elicits sexual immaturities in offspring: the disruption in folic acid metabolism and restoration by α-lipoic acid supplementation.

○Yuki Ishiiyama1, Takayuki Koga2, Yuji Ishii1 (1. Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 2. Daiichi Univ. Pharm.)

[GS02-3]Epigenetic modifications in sperm caused by methylphenidate: Implications for the next generation and their reversibility

○Kanata Akaike1, Asuka Kaizaki- Mitsumoto1, Satoshi Numazawa1 (1. Showa Med Univ Grad School Pharm)

[GS02-4]Changes in microglial responses induced by differences in adsorbed molecules on nanoparticle surfaces and their implications for developmental neurotoxicity

○Chihiro Kai1, Ken Tachibana1, Ken Takeda1, Atsuto Onoda1 (1. Sanyo-Onoda City University, Departiment of Pharmacy)

[GS02-5]MEA-based analysis of gene–environment interactions in developing neural networks

○Shunsuke Wakabayashi1, Ami Oguro1, Masatsugu Miyara1, Yasunari Kanda2, Yaichiro Kotake1 (1. Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2. NIHS)

[GS02-6]Elucidating the mechanisms underlying neural network responses to early developmental exposure to valproic acid

○Mimo Hashizume1, Hideko Sone1 (1. Yokohama University of Pharmacy, Graduate School of Pharmaceutical Sciences)

総括