講演情報
[7p-N306-7]Using the boundaries of ferroelectric domains as a potential virtual electrode for living cells
〇ALEXIS BOROWIAK1,2, YOHEI KONO1,2, TAKESHI SHIMI1,2, TAKESHI FUKUMA1,2 (1.Kanazawa Univ., 2.NanoLSI)
キーワード：
Nanoendoscopy-AFM、Ferroelectric domain boundaries、Nuclear membrane
In recent years, interest has grown in using ferroelectric materials as virtual electrodes for investigating biological specimens. Ferroelectric materials have been used to study the electromechanical properties of cell and nucleus membranes, showing that surface-screened charges influence cell mechanics. We aim to establish a method for exploring living cell mechanics with an AFM nanoneedle on electrical stray fields between polarized domains. Our results suggest that the field gradient at opposite ferroelectric domains affects mechanical properties. We observed reduced elastic properties in the cell membranes of cells grown on a Periodically Poled Lithium Niobate crystal compared to those on a Lithium Niobate crystal. The cell membrane is penetrated more easily with minimal force required. These findings open new opportunities for understanding and modulating cellular inner dynamics under electrical stray fields at 180° ferroelectric domain walls.