セッション詳細
[HT-02]ホットトピックス02 International collaboration in 2025: autoimmune encephalitis and its related disorders
2025年5月22日(木) 15:10 〜 17:10
第05会場(大阪国際会議場10F 会議室1009)
座長：野原 千洋子（東京都保健医療公社荏原病院 神経内科）, 河内 泉（新潟大学医歯学総合病院・脳研究所・脳神経内科学. 新潟大学大学院医歯学総合研究科総合医学教育センター）
後援：日本神経免疫学会
This symposium aims to shed light on update 2025 of clinical and research issues of 'autoimmune encephalitis (AE) and its related disorders' based on international collaboration. The presenters will revisit the progress of basic research and clinical issues for 'AE and its related diseases' through international collaboration (US, Taiwan, and Japan). It will map the global research landscape, clarify the differences derived from genetic/environmental factors and pharmaceutical regulations, and provide the evolution of research topics, including neuroscience and new clinical practice guidelines for 'AE and its related disorders'. Each presenter's talks (95 min) will be followed by panel discussion (25 min).
[HT-02-1]Autoimmune encephalitis and NMOSD: translational immunological findings
Sarosh R. Irani (Department of Neurology, Mayo Clinic, Jacksonville, Florida)
Sarosh R Irani BMBCh MA (Oxon) DPhil FRCP
• Professor of Neurology and Neurosciences, Mayo Clinic Florida
• MRC Senior Clinical Fellow, University of Oxford
• Associate Editor @Brain
RESEARCH SUMMARY
Sarosh Irani is a clinician-scientist who established the Oxford Autoimmune Neurology Group and is now Professor of Neurology and Neurosciences at the Mayo Clinic, Florida. His contributions to the field include the discovery of LGI1 and CASPR2 antibodies, their related phenotypes in particular faciobrachial dystonic seizures, their HLA associations and the immunology underlying autoimmune encephalitis and neuromyelitis optica syndromes. His work highlights clinical phenotypes and characterizes the cellular immunology underlying these conditions towards disease causation and cure. He has a H-index of 64, has published over 200 peer-reviewed publications and is Associate Editor at the journal Brain.
• Professor of Neurology and Neurosciences, Mayo Clinic Florida
• MRC Senior Clinical Fellow, University of Oxford
• Associate Editor @Brain
RESEARCH SUMMARY
Sarosh Irani is a clinician-scientist who established the Oxford Autoimmune Neurology Group and is now Professor of Neurology and Neurosciences at the Mayo Clinic, Florida. His contributions to the field include the discovery of LGI1 and CASPR2 antibodies, their related phenotypes in particular faciobrachial dystonic seizures, their HLA associations and the immunology underlying autoimmune encephalitis and neuromyelitis optica syndromes. His work highlights clinical phenotypes and characterizes the cellular immunology underlying these conditions towards disease causation and cure. He has a H-index of 64, has published over 200 peer-reviewed publications and is Associate Editor at the journal Brain.
[HT-02-2]Autoimmune encephalitis and its related disorders in Taiwan: update 2025
Mei-Yun Cheng (Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine)
Education：
1996-2003 Chung Shan Medical University, Taiwan
2010-2017 PhD, National Tsing Hua University, Taiwan
Employment Record：
2008 Attending, Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan
2013- Assistant Professor, Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan
2019- Director, Section of Functional Neurology and Epilepsy, Chang Gung Memorial Hospital, Linkou, Taiwan
Professional Appointments:
Director of Taiwan Epilepsy Society
Direction of Taiwan Neuroimmunology Medical Society
Research Interests:
1. Epilepsy
2. Autoimmune encephalitis
3. Multiple sclerosis
4. Spinal cord infarction
Selective Publications：
1. Cheng MY, Ho HC, Hsu JL, Wang Y, Chen L, Lim SN, Liao MF, Ro LS. Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines. Diseases. 2024;12. doi: 10.3390/diseases12030060
2. Hsu JL, Cheng MY, Su JJ, Liao M-F, Kuo HC, Chu CC, Chen CM, Chang KH, Chang CW, Wu YR, et al. Impact of comorbidities on relapsing rates of Neuromyelitis Optica Spectrum Disorders: Insights from a longitudinal study in Taiwan. Multiple Sclerosis and Related Disorders. 2024;87. doi: 10.1016/j.msard.2024.105683
3. Cheng MY, Hsu JL, Liao MF, Hsu HC, Weng YC, Chang KH, Chang HS, Kuo HC, Huang CC, Lyu RK, Lin KJ, Ro LS*. A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies. Scientific Reports. 2019 May 15;9(1): 7435.
1996-2003 Chung Shan Medical University, Taiwan
2010-2017 PhD, National Tsing Hua University, Taiwan
Employment Record：
2008 Attending, Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan
2013- Assistant Professor, Neurology, Chang Gung Memorial Hospital, Linkou, Taiwan
2019- Director, Section of Functional Neurology and Epilepsy, Chang Gung Memorial Hospital, Linkou, Taiwan
Professional Appointments:
Director of Taiwan Epilepsy Society
Direction of Taiwan Neuroimmunology Medical Society
Research Interests:
1. Epilepsy
2. Autoimmune encephalitis
3. Multiple sclerosis
4. Spinal cord infarction
Selective Publications：
1. Cheng MY, Ho HC, Hsu JL, Wang Y, Chen L, Lim SN, Liao MF, Ro LS. Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines. Diseases. 2024;12. doi: 10.3390/diseases12030060
2. Hsu JL, Cheng MY, Su JJ, Liao M-F, Kuo HC, Chu CC, Chen CM, Chang KH, Chang CW, Wu YR, et al. Impact of comorbidities on relapsing rates of Neuromyelitis Optica Spectrum Disorders: Insights from a longitudinal study in Taiwan. Multiple Sclerosis and Related Disorders. 2024;87. doi: 10.1016/j.msard.2024.105683
3. Cheng MY, Hsu JL, Liao MF, Hsu HC, Weng YC, Chang KH, Chang HS, Kuo HC, Huang CC, Lyu RK, Lin KJ, Ro LS*. A comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies. Scientific Reports. 2019 May 15;9(1): 7435.
[HT-02-3]日本におけるMOG抗体関連疾患：2025年アップデート
中島 一郎 (東北医科薬科大学医学部 脳神経内科学)
1994 Graduated from Tohoku University
1999 Clinical Fellow, Department of Neurology, Tohoku University
2001 Assistant Professor, Department of Neurology, Tohoku University
2007 Visiting Scholar, Montreal Neurological Institute, McGill University
2008 Senior Lecturer & Assistant Professor, Department of Neurology, Tohoku University
2013 Associate Professor, Department of Neurology, Tohoku University
2017 Professor, Division of Neurology, Tohoku Medical and Pharmaceutical University
Currently President of the Japanese Society of Neuroimmunology, Board Certified Member of the Japanese Society of Neurology and the Japanese Society of Internal Medicine, and Councilor of the Japanese Society of Neurology and the Japanese Society of Neurotherapeutics.
1999 Clinical Fellow, Department of Neurology, Tohoku University
2001 Assistant Professor, Department of Neurology, Tohoku University
2007 Visiting Scholar, Montreal Neurological Institute, McGill University
2008 Senior Lecturer & Assistant Professor, Department of Neurology, Tohoku University
2013 Associate Professor, Department of Neurology, Tohoku University
2017 Professor, Division of Neurology, Tohoku Medical and Pharmaceutical University
Currently President of the Japanese Society of Neuroimmunology, Board Certified Member of the Japanese Society of Neurology and the Japanese Society of Internal Medicine, and Councilor of the Japanese Society of Neurology and the Japanese Society of Neurotherapeutics.
[HT-02-4]Anti-NMDAR/anti-LGI1 encephalitis in Japan: update 2025
河内 泉1,2 (1.新潟大学医歯学総合病院 脳研究所 脳神経内科学, 2.新潟大学大学院医歯学総合研究科 医学教育センター)
Izumi Kawachi, M.D., Ph.D. is presently an Associate Professor in Department of Neurology, Brain Research Institute, Niigata University, and Medical Education Center, Niigata University School of Medicine, Niigata, Japan. She is a director of the Japanese Society for Neuroimmunology, and a councilor of the Japanese Society for Neuropathology, the Japanese Society of Neurology and the Japanese Society of Neurological Therapeutics, as well as serving as a Member of the MS/NMOSD Guidelines Committee 2017 and 2023. Dr. Kawachi graduated from Niigata University in 1993 (MD) and earned her PhD from Niigata University in 2002. Dr. Kawachi undertook training in neurology at Brain Research Institute, Niigata University and then engaged in research of innate immunology as a research associate in Prof. Marco Colonna’s lab, Department of Pathology and Immunology, Washington University, School of Medicine, St. Louis, USA. Her principal research activity has been in MS/NMO/autoimmune encephalitis.