セッション詳細

[LB]Late Breaking Symposium

2025年5月21日(水) 13:20 〜 15:20
第06会場(大阪国際会議場10F 会議室1008)
座長:西郷 和真(近畿大学病院 遺伝子診療部・脳神経内科), 奥野 龍禎(大阪大学大学院医学研究科 神経内科学)

[_LB-1]Whole Brain Single Neuron Atlas Uncovers a Novel Neurodegenerative Niche, “Microglia Security Hole”

Tomoki T Mitani1,2,3, Kosei Yamaura3, Rikuhiro G. Yamada3,4, Katsuhiko Matsumoto3, Etsuo A. Susaki3,5,6,7, Naruhiko Sahara2,8,9, Rin Yanai8, Kensuke Ikenaka1, Shiying Jiang1, Hideki Hayakawa1, Hideki Mochizuki1, Kousuke Baba1, Hiroki R. Ueda3,4 (1.Department of Neurology, Graduate School of Medicine, The University of Osaka, 2.Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, 3.Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, 4.Department of Systems Biology, Institute of Life Science, Kurume University, Fukuoka, 5.Department of Biochemistry and Systems Biomedicine, Graduate School of Medicine, Juntendo University, Tokyo, 6.Nakatani Biomedical Spatialomics Hub, Graduate School of Medicine, Juntendo University, Tokyo, 7.Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, 4-9-1, Anagawa, Inage-ku, Chiba, 8.Advanced Neuroimaging Center, Institute for Quantum Medical Sciences, National Institutes for Quantum Science and Technology, Chiba, 9.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Aichi)

[_LB-2]Structure and Thermostability of the Transthyretin G47R Variant Protein: Implications for the Early Onset of Hereditary Transthyretin Amyloidosis

Naoki Yamamoto1, Miki Senda2, Kou Honda3, Satoru Nagatoishi4, Ryuichi Kato2, Kouhei Tsumoto3, Atsuo Tamura3, Toshiya Senda2, Naoya Shibayama1, Tohru Matsuura5 (1.Division of Biophysics, Department of Physiology, Jichi Medical University, 2.Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 3.Department of Chemistry, Graduate School of Science, Kobe University, 4.Department of Bioengineering, School of Engineering, The University of Tokyo, 5.Division of Neurology, Jichi Medical University Hospital)

[_LB-3]Measurement of lecanemab-associated amyloid-β protofibrils in cerebrospinal fluid in patients with Alzheimer's disease

Moeko Noguchi-Shinohara1, Kazuyoshi Shuta2, Hidetomo Murakami3, Yukiko Mori3, Junji Komatsu1, Chizuru Kobayashi2, Steven Hersch4, Kanta Horie4, Kenjiro Ono1 (1.Department of Neurology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, 2.Deep Human Biology Learning (DHBL), Eisai Co., Ltd, Tsukuba, 3.Department of Neurology, School of Medicine, Showa University, Tokyo, 4.Deep Human Biology Learning (DHBL), Eisai Inc., Nutley, NJ)

[_LB-4]Astrocyte Gi-GPCRs ameliorate cognitive dysfunction in Alzheimer’s disease mice

Fumito Endo1,6, Joselyn Soto1, Vijaya Pandey3, Zhe Qu4, Viviana Gradinaru4, James Wohlschlegel3, Riki Kawaguchi5, Baljit S. Khakh1,2 (1.Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, 2.Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, 3.Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, 4.Division of Biology and Biological Engineering, California Institute of Technology, 5.Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, 6.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University)

[_LB-5]Pentatricopeptide repeat protein targeting CUG repeat RNA ameliorates RNA toxicity in a myotonic dystrophy type 1 mouse model

Joe Nemoto1, Takayoshi Imai2, Maiko Miyai3, Yusuke Yagi2,4, Osamu Nakanishi2, Hideki Mochizuki3, Masayuki Nakamori1,3 (1.Department of Neurology, Graduate School of Medicine, Yamaguchi University, 2.EditForce, Inc, 3.Department of Neurology, Osaka University Graduate School of Medicine, 4.Faculty of Agriculture, Kyusyu University)

[_LB-6]Phase I/II trial of iPSC-derived dopaminergic cells for Parkinson's disease

Nobukatsu Sawamoto1,8, Daisuke Doi2,8, Etsuro Nakanishi1,8, Masanori Sawamura1,8, Takayuki Kikuchi3, Hodaka Yamakado1, Yosuke Taruno1, Atsushi Shima1, Tetsuhiro Kikuchi2, Asuka Morizane2, Satoe Hiramatsu2, Takayuki Anazawa4, Takero Shindo5, Kentaro Ueno6, Satoshi Morita6, Yoshiki Arakawa3, Yuji Nakamoto7, Susumu Miyamoto3, Ryosuke Takahashi1, Jun Takahashi2 (1.Department of Neurology, Kyoto University Graduate School of Medicine, 2.Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, 3.Department of Neurosurgery, Kyoto University Graduate School of Medicine, 4.Department of Surgery, Kyoto University Graduate School of Medicine, 5.Department of Hematology/Oncology, Kyoto University Graduate School of Medicine, 6.Department of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, 7.Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 8.These authors contributed equally: Nobukatsu Sawamoto, Daisuke Doi, Etsuro Nakanishi, Masanori Sawamura)