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Wed. Jun 19, 2024

Thu. Jun 20, 2024

Fri. Jun 21, 2024

Sat. Jun 22, 2024

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pHストレスは細胞競合を阻害することにより変異細胞の蓄積を引き起こす

pH-stress causes accumulation of cells with <em>de novo</em> mutations by disrupting cell competition

The drastic advancement in industrialization and technology, and the growth in human population in the past century have resulted in unprecedented environmental changes in the human history. The production of large amounts of synthetic  compounds as well as pollutants poses a risk to our ecosystem and induces negative effects on the health of wildlife and human beings. With the emergence of the global problem of chemical contamination, such as endocrine-discrupting chemicals (EDCs), Per- and polyfluoroalkyl substances (PFAS), and microplastecs, the adverse biological effects of such pollutants are gaining attention in the publics. There is an increasing need for the identification and quantification of all these ubiquitous chemical contaminants. Studies in toxicology field have been continuous be performed, however, more detailed reseraches on potential developmental hazardous of such chemicals are requried. It is especially important to understand the possible toxic effect on the developing embryo. The symposium will introduce the current developmental toxicology studies using various experimental models, and omics methods; and finish by discussing the future directions of the field. We hope tha tthe workshop could induce the concept of integrating the developmental biology in the toxicology studies.

Developmental Toxicology and toxicogenomics (in English)

The 57th Annual Meeting of the Japanese Society of Developmental Biologists

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[WS04-06]pH-stress causes accumulation of cells with de novo mutations by disrupting cell competitionpHストレスは細胞競合を阻害することにより変異細胞の蓄積を引き起こす

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