Session Details
Developmental Toxicology and toxicogenomics (in English)
Wed. Jun 19, 2024 2:30 PM - 4:30 PM JST
Wed. Jun 19, 2024 5:30 AM - 7:30 AM UTC
Wed. Jun 19, 2024 5:30 AM - 7:30 AM UTC
Room E(Miyako Messe(B1F)/Meeting Room)
Chairpersons:William Ka Fai TSE(Kyushu Univ.)
The drastic advancement in industrialization and technology, and the growth in human population in the past century have resulted in unprecedented environmental changes in the human history. The production of large amounts of synthetic compounds as well as pollutants poses a risk to our ecosystem and induces negative effects on the health of wildlife and human beings. With the emergence of the global problem of chemical contamination, such as endocrine-discrupting chemicals (EDCs), Per- and polyfluoroalkyl substances (PFAS), and microplastecs, the adverse biological effects of such pollutants are gaining attention in the publics. There is an increasing need for the identification and quantification of all these ubiquitous chemical contaminants. Studies in toxicology field have been continuous be performed, however, more detailed reseraches on potential developmental hazardous of such chemicals are requried. It is especially important to understand the possible toxic effect on the developing embryo. The symposium will introduce the current developmental toxicology studies using various experimental models, and omics methods; and finish by discussing the future directions of the field. We hope tha tthe workshop could induce the concept of integrating the developmental biology in the toxicology studies.
[WS04-01]Developmental, Reproductive and Neurotoxic Effect of Microplastics Exposure
Shuqin Ji1,2, Ziyi Lin2, Huixin Tao2, Haopu Wang2, Xiaochun Shan2, *Lei Li2 (1. Department of Urology and Andrology, The First Affiliated Hospital, Sun Yat-sen University, 2. Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)
[WS04-02]In-utero exposure to PFOS affects epigenetics and metabolism in the offspring of mice.
*Chris Kong-chu Wong1 (1. Hong Kong Baptist University)
[WS04-03]Developmental toxicity testing in human iPS cells through disruption of signal interactionシグナル伝達相互作用のかく乱を基にしたヒトiPS細胞を用いた発生毒性試験法の開発
*YUSUKE OKUBO1,2, Kashu Mizota1,2, Rintaro Ohara1,2, Rieko Matsuura1, Yoko Hirabayashi1, Yoshihiro Nakajima3, Junji Fukuda2 (1. National Institute of Health Sciences, 2. Yokohama National University, 3. National Institute of Advanced Industrial Science and Technology)
[WS04-04]Hypoxia causes epigenetic transgenerational reproductive impairments in marine fish
*Keng Po Lai1, Yi Yang2, Rudolf Shiu Sun Wu3 (1. Key Laboratory of Environmental Pollution and Integrative Omics, Guilin Medical University, 2. State Key Laboratory of Marine Pollution, City University of Hong Kong, 3. State Key Laboratory of Marine Pollution, Education University of Hong Kong)
[WS04-05]General Toxicity of Environmental Exposure to Perfluorobutane Sulfonate (PFBS) in Zebrafish Embryos
*Zulvikar Syambani Ulhaq1,2, William Ka Fai Tse2 (1. Research Center for Pre-clinical and Clinical Medicine, National Research and Innovation Agency, Republic of Indonesia, Cibinong 16911, Indonesia, 2. Laboratory of Developmental Disorders and Toxicology, Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan)
[WS04-06]pH-stress causes accumulation of cells with de novo mutations by disrupting cell competitionpHストレスは細胞競合を阻害することにより変異細胞の蓄積を引き起こす
*Yuki Akieda1, Tohru Ishitani1 (1. Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University)