Presentation Information
[3P101]Development of a stable fabrication process for lateral voltage applied devices using flexible insulating materials
*Tatsuya Nomoto1,2, Shunsuke Nomura1,3, Teng Ma4, Daisuke Tadaki1, Watanabe Kyoya1,2, Yuzuru Tozawa5, Ayumi Hirano-Iwata1,4 (1. Research Institute of Electrical Communication, Tohoku University, 2. Graduate School of Biomedical Engineering, Tohoku University, 3. Graduate School of Engineering, Tohoku University, 4. Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, 5. Graduate School of Science and Engineering , Saitama University)
In this study, we developed a new method of applying lateral voltage to artificial cell membranes and found that this restores the activity of human voltage-gated Na ion channels. However, conventional lateral voltage devices have their challenges. Therefore, we developed a new device fabrication process using Au as the electrode metal and Sci-Top resin as the insulating layer. In this process, microholes were formed in a Teflon film and electrodes were sputtered into them to construct the device. This process resulted in long-lasting, stable side-voltage devices. Experiments evaluated the performance of the fabricated devices and showed that the establishment of a new system for analyzing ion channel function could contribute to the development of new drugs and scientific understanding in the future.