講演情報
[16a-K306-10]Peptide Function Screening Using Machine Learning-Enhanced Polydiacetylene Sensors
〇(D)Jiali Chen1, Kaori Sugihara1 (1.Univ. of Tokyo)
キーワード：
Polydiacetylene、Hyperspectral imaging、Machine learning
Peptides have emerged as a cornerstone of therapeutic research, drawing significant attention for their therapeutic potential and biocompatibility. While thousands of peptides occur naturally and many can be synthesized, accelerating their functional discovery remains crucial for healthcare advancement.
Polydiacetylene, a sensing polymer, exhibits a blue-to-red color transition in response to stimuli including heat, light, pH, and biomolecules. This polymer serves as an effective platform for peptide screening through its visible color changes, simple synthesis, and cost-effectiveness. Our research has revealed its capability to identify various stimuli, and we are developing its application for peptide identification. Our approach uses hyperspectral imaging to collect pixel-level spectral data, enabling the monitoring of molecular-membrane interactions that help interpret peptide functions. We have developed an ensemble Multi-Layer Perceptron (MLP) model as a smart platform to automate analysis, screening peptides forsimilar functions, enabled rapid,efficient durg screening for therapeutic applications.
Polydiacetylene, a sensing polymer, exhibits a blue-to-red color transition in response to stimuli including heat, light, pH, and biomolecules. This polymer serves as an effective platform for peptide screening through its visible color changes, simple synthesis, and cost-effectiveness. Our research has revealed its capability to identify various stimuli, and we are developing its application for peptide identification. Our approach uses hyperspectral imaging to collect pixel-level spectral data, enabling the monitoring of molecular-membrane interactions that help interpret peptide functions. We have developed an ensemble Multi-Layer Perceptron (MLP) model as a smart platform to automate analysis, screening peptides forsimilar functions, enabled rapid,efficient durg screening for therapeutic applications.