講演情報
[16a-P07-22]Synthesis of Chiral Gold Nanostructures on Mesoporous Gold Substrates for Chiral Discrimination by surface-enhanced Raman Spectroscopy
〇(D)Junhe WANG1, Kenta Nakagawa1, Yuta Shiga1, Takuya Nakanishi1, Yusuke Yamauchi2,3,4, Toru Asahi1 (1.Waseda Univ., 2.Nagoya Univ., 3.Univ. of Queensland, 4.NIMS)
キーワード：
Chiral Nanostructure、SERS sensing
Chirality plays an important role in our lives; more than 90% of biologically active molecules, including most amino acids and sugars, often differ between the enantiomers that are non-superimposable mirror images of each other molecules. Differences in their chiral configurations can result in distinct biological activities or even toxicity. Consequently, the rapid and precise discrimination of enantiomers is essential for research on chiral bioactive compounds. Despite significant progress in chiral recognition techniques, the efficient and accurate identification of enantiomers remains a challenging endeavor. For highly sensitive chiral discrimination, we focused on the potential of surface-enhanced Raman spectroscopy (SERS), which enhances the Raman scattering signals of molecules adsorbed onto metal nanostructure surfaces. By introducing chiral structures into these metal nanostructure surfaces, differences in signal intensities between the analyte enantiomers can be observed, enabling enantiomeric recognition. In this study, we focused on the electro-chemical synthesis of chiral gold nanostructures on mesoporous gold substrates, characterized by numerous mesopores with diameters of several tens of nanometers. The mesoporous gold was synthesized by an electrodeposition method using soft-template block copolymers. To introduce chirality, an additional layer of chiral gold nanostructures was deposited onto the mesoporous gold through subsequent electrodeposition from an electrolyte solution containing a gold precursor and a chiral additive. In this presentation, we discuss the interaction between the gold precursor and the chiral additive in the electrolyte solution by using spectroscopic methods such as CD, NMR, and XAFS spectra and their influence on the nanostructures. In addition, we investigated the potential for enantiomeric discrimination by measuring the SERS spectra of several analyte molecules adsorbed on the films we synthesized.