講演情報
[16p-K402-15]Modulating the electromechanical properties of the nucleus in living cells via ferroelectric surfaces
〇ALEXIS BOROWIAK1,2, TAKEHIKO ICHIKAWA1,2, YOHEI KONO1,2, TAKESHI SHIMI1,2, TAKESHI FUKUMA1,2 (1.Kanazawa Univ., 2.NanoLSI)
キーワード：
Nanoendoscopy-AFM、Ferroelectric surface、Inorganic ions
In the last 10 years, interest has emerged in using ferroelectric materials as virtual electrodes to investigate biological specimens. Effectively, applying a direct electric field to cells often requires using metallic, limited-sized electrodes that are only sometimes biologically compatible. Ferroelectric materials are a promising alternative solution due to their unique, spontaneous electric polarization, as there is no need for an external circuit or electrical source to be used. In this work, we report a new method for investigating the mechanical properties of living cells grown on ferroelectric crystal surfaces with different polarities using a new technique called nanoendoscopy-AFM. This technique allows for inserting an AFM nano-needle inside a cell and studying the electromechanical properties of the cell and nucleus membrane. Our findings suggest that ferroelectric surfaces can be used to modulate the external and internal ionic environment of cells, thus affecting cell stiffness depending on the polarity of the ferroelectric crystal and ionic species around cells.