Presentation Information
[P151]Development of Natural Polymer-Coated Nanocarriers for Enhanced Oral Mucosal Nutrient Delivery
*Woojin Lee1, Eunji Kim2, Eunryung Kim1,2, Hosup Jung1,2 (1. CFB, 2. Nbiocell)
Keywords:
Nanocarriers,Natural polymer coating,Oral mucosal permeability,Nutrient delivery
1. Purpose
Efficient oral mucosal delivery of nutraceuticals is increasingly important in both functional food and pharmaceutical applications. This study aims to develop a (liposomal) nanocarrier coated with natural polymers to improve mucosal permeability and colloidal stability of encapsulated functional compounds.
2. Methods
Nanocarriers encapsulating functional compounds, including vitamins and L-theanine, were prepared and homogenized using a microfluidizer to obtain uniform nanoscale particles. To improve mucoadhesive properties and colloidal stability, they were surface-coated with natural polymers, such as chitosan or pectin. Physicochemical properties, including particle size, zeta potential, and morphology, were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The stability of the coated nanocarriers was assessed by incubation in a simulated oral mucosal environment. Furthermore, the effects of different polymer coatings on oral mucosal permeability and structural integrity were systematically investigated.
3. Results
Nanocarriers with an average size of 80–200 nm were successfully prepared. Surface coating with natural polymers, particle sizes increased by 5–40 nm, and changes in zeta potential confirmed effective surface coating. The coated nanocarriers exhibited excellent stability in a simulated oral mucosal environment. Furthermore, differences in oral mucosal permeability and structural integrity were observed depending on the polymer type.
Efficient oral mucosal delivery of nutraceuticals is increasingly important in both functional food and pharmaceutical applications. This study aims to develop a (liposomal) nanocarrier coated with natural polymers to improve mucosal permeability and colloidal stability of encapsulated functional compounds.
2. Methods
Nanocarriers encapsulating functional compounds, including vitamins and L-theanine, were prepared and homogenized using a microfluidizer to obtain uniform nanoscale particles. To improve mucoadhesive properties and colloidal stability, they were surface-coated with natural polymers, such as chitosan or pectin. Physicochemical properties, including particle size, zeta potential, and morphology, were characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The stability of the coated nanocarriers was assessed by incubation in a simulated oral mucosal environment. Furthermore, the effects of different polymer coatings on oral mucosal permeability and structural integrity were systematically investigated.
3. Results
Nanocarriers with an average size of 80–200 nm were successfully prepared. Surface coating with natural polymers, particle sizes increased by 5–40 nm, and changes in zeta potential confirmed effective surface coating. The coated nanocarriers exhibited excellent stability in a simulated oral mucosal environment. Furthermore, differences in oral mucosal permeability and structural integrity were observed depending on the polymer type.
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