Presentation Information
[3Ca02]Effects of Roasted Brown Rice Coffee on Lipid Metabolism in Rats Fed a High-Fat and High-Cholesterol Diet
*Sei ISHIKAWA1, Kyohei HIGUCHI2, Rikuto KAWAI2, Yuri HANEISHI2, Jun YAMAUCHI1,2, Tadasu FURUSHO3, Yuri TANIOKA1,2 (1. Grad. Sch., Dept. of Int’l Food & Agri. Sci., Tokyo Univ. of Agri., 2. Dept. of Int'l Food & Agri. Sci., Fac. of Int'l Agri. and Food St., Tokyo Univ. of Agri., 3. Dept. of Nutri. & Mgmt., Tokyo Seiei Coll.)
Keywords:
Roasted brown rice,Dietary fiber,Bile acid,Lipid metabolism,Rats
【Objective】 The rising prevalence of lifestyle-related diseases, particularly dyslipidemia—a key risk factor for cardiovascular disease—poses a major health issue. This study focused on roasted brown rice coffee (RBR), produced by roasting and powdering brown rice. RBR contained rich dietary fiber and has antioxidant and bile acid-binding capacity in vitro, but its effects remain unclear in vivo. This study aimed to investigate the effects of RBR on lipid metabolism in rats.
【Methods】 Six-week-old male SD rats were fed for 8 weeks with one of the following diets: a high-fat and high-cholesterol diet (HF; AIN-93G + 20% lard + 1% cholesterol), the same diet with precooked brown rice powder (BR), or with RBR powder (RBR), an equal amount of dietary fiber content. Rats were pair-fed, with ad libitum water. Feces were collected during the final 3 days for bile acid measurement.
【Results】 Total amount of food intake did not statistically significant among groups. However, the RBR group showed significantly suppressed weight gain compared to the BR group during weeks 4–7. Both BR and RBR groups exhibited reduced hepatic hypertrophy and significantly lower hepatic lipid, and lipid peroxidation levels compared to the HF group. Fecal bile acid excretion was significantly higher in the RBR group, suggesting enhanced bile acid excretion via soluble fiber. No significant improvements were observed in final body weight, adipose tissue weight, serum lipids, AST/ALT levels, hepatic TG and TC levels. These findings indicate that RBR may promote bile acid excretion and suppress weight gain and hepatic lipid accumulation, though longer or higher intake may be needed for systemic lipid improvements.
【Methods】 Six-week-old male SD rats were fed for 8 weeks with one of the following diets: a high-fat and high-cholesterol diet (HF; AIN-93G + 20% lard + 1% cholesterol), the same diet with precooked brown rice powder (BR), or with RBR powder (RBR), an equal amount of dietary fiber content. Rats were pair-fed, with ad libitum water. Feces were collected during the final 3 days for bile acid measurement.
【Results】 Total amount of food intake did not statistically significant among groups. However, the RBR group showed significantly suppressed weight gain compared to the BR group during weeks 4–7. Both BR and RBR groups exhibited reduced hepatic hypertrophy and significantly lower hepatic lipid, and lipid peroxidation levels compared to the HF group. Fecal bile acid excretion was significantly higher in the RBR group, suggesting enhanced bile acid excretion via soluble fiber. No significant improvements were observed in final body weight, adipose tissue weight, serum lipids, AST/ALT levels, hepatic TG and TC levels. These findings indicate that RBR may promote bile acid excretion and suppress weight gain and hepatic lipid accumulation, though longer or higher intake may be needed for systemic lipid improvements.
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