Presentation Information
[3Ap09]Solubilization of curcumin in turmeric powder using yeast-derived polysaccharide nanoparticles
*kazuhito zinno1, Otoya Aoyama2, Sabi Mineo1, Koizumi Keiich2 (1. DKS Co. Ltd., 2. University of Toyama)
Keywords:
Yeast,Polysaccharide,Nanoparticle,Turmeric,Curcumin
[Objective] Dr. Koizumi of Toyama University has found that polysaccharide nanoparticles are universally produced in water extract when plants and fungi, including herbal medicines, are boiled in water. We currently propose the hypothesis that these polysaccharide nanoparticles contribute to the solubilization of poorly water-soluble components in foods using water extracts from plants and fungi. In this study, we investigated the polysaccharide nanoparticles from food yeast to determine their composition and their ability to solubilize poorly water-soluble components found in herbal medicines and plant foods.
[Method] A hot water extract of brewer's yeast was fractionated with ethanol and dried to obtain a powder containing polysaccharide nanoparticles (hereafter referred to as polysaccharide nanoparticles). To verify the solubilization ability of poorly water-soluble components, polysaccharide nanoparticles were added to an aqueous suspension of turmeric powder and mixed, and the amount of curcumin solubilized in water was quantified using absorbance.
[Results] Nanoparticles of around 60 nm and 10 nm were observed by atomic force microscope and identified as glycogen and mannan, respectively. The solubility of curcumin alone in water was less than 1 µg/mL, but when an aqueous suspension containing 5% turmeric powder was mixed at room temperature for one day, the concentration of curcumin dissolved in the supernatant was 5 µg/mL. Furthermore, when 1% polysaccharide nanoparticles were added, the concentration increased to 14 µg/mL, indicating the solubilization effect of polysaccharide nanoparticles on curcumin.
[Method] A hot water extract of brewer's yeast was fractionated with ethanol and dried to obtain a powder containing polysaccharide nanoparticles (hereafter referred to as polysaccharide nanoparticles). To verify the solubilization ability of poorly water-soluble components, polysaccharide nanoparticles were added to an aqueous suspension of turmeric powder and mixed, and the amount of curcumin solubilized in water was quantified using absorbance.
[Results] Nanoparticles of around 60 nm and 10 nm were observed by atomic force microscope and identified as glycogen and mannan, respectively. The solubility of curcumin alone in water was less than 1 µg/mL, but when an aqueous suspension containing 5% turmeric powder was mixed at room temperature for one day, the concentration of curcumin dissolved in the supernatant was 5 µg/mL. Furthermore, when 1% polysaccharide nanoparticles were added, the concentration increased to 14 µg/mL, indicating the solubilization effect of polysaccharide nanoparticles on curcumin.
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