[7P-O] [7P-O] Poster Presentation 01 (47)

[7P-O-392] The Mathematical Modeling and Simulation of Amino acid-dependent TSC2 Dephosphorylation by Lysosome-PP2A regulates mTORC1 Signaling Transduction

Takanori Nakamura^1,2,10, Shigeyuki Nada³, Masaki Matsumoto⁴, Kazuki Ikeda⁵, Naohiko Koshikawa^5,6, Tatsuya Sawaki², Mutsuhiro Takekawa^1,7, Takashi Suzuki⁸, Masato Okada^3,9, *Nuha binti Loling Othman⁸ (1. Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of Tokyo, 2. Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, 3. Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 4. Department of Omics and Systems Biology, Niigata University, 5. Department of Life Science and Technology, Tokyo Institute of Technology, 6. Clinical Cancer Proteomics Laboratory, Kanagawa Cancer Center Research institute, 7. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 8. Center for Mathematical Modeling and Data Science, Osaka University, 9. Center for Advanced Modalities and Drug Delivery System, Osaka University, 10. Present Address: Division of Pathology, Proteo-Science Center and Graduate School of Medicine, Ehime University)

Keywords:

Mathematical simulation,mTORC1 signaling pathway,PP2A,lysosomal TSC2 localization

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