[WS09] Understanding, measuring and manipulating protein lifetimes[J] | Joint Meeting of JSCB 77th and JSDB 58th

Session Details

Workshop

[WS09]Understanding, measuring and manipulating protein lifetimes[J]

Thu. Jul 17, 2025 9:00 AM - 10:15 AM JST
Thu. Jul 17, 2025 12:00 AM - 1:15 AM UTC

Room D(9F Conference Room901)

Chairpersons:Shigeo Murata(Univ. of Tokyo), Yasushi Saeki(Univ. of Tokyo)

The regulation of protein lifetimes in cells governs a wide range of cellular functions, and disruptions in this regulation can lead to various diseases. Drug development targeting these regulatory mechanisms is advancing globally. However, key challenges remain, such as elucidating the molecular mechanisms and principles underlying protein lifetime regulation, developing techniques for precise and comprehensive measurement of protein lifetimes, and creating technologies to manipulate the lifetimes of specific proteins. In this workshop, young scientists will showcase the latest advances in their research at the cutting edge of these fields.

9:00 AM - 9:15 AM JST(12:00 AM - 12:15 AM UTC)

[WS09-01]Precursor occupancy controls mitochondrial import channel via proteolysis.

*Koji Yamano^1,2 (1. Institute of Science Tokyo, 2. Tokyo Metropolitan Institute of Medical Science)

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9:15 AM - 9:30 AM JST(12:15 AM - 12:30 AM UTC)

[WS09-02]Pathogenic role of unique ubiquitin ligase mysterin in moyamoya disease.

*Minami Orii¹, Daisuke Morito¹ (1. Showa Medical University)

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9:30 AM - 9:45 AM JST(12:30 AM - 12:45 AM UTC)

[WS09-03]Identification of cellular signaling pathways regulating targeted protein degradation

*Yuki Mori^1,2, Yoshino Akizuki^1,2, Rikuto Honda^1,2, Fumiaki Ohtake^1,2 (1. Institute for Advanced Life Science, Hoshi University, 2. Graduate school of Pharmaceutical Science, Hoshi University)

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9:45 AM - 10:00 AM JST(12:45 AM - 1:00 AM UTC)

[WS09-04]Development of PSLip-MS: a novel method for direct identification and quantification of proteasome substrates

*Takuya Tomita¹, Kurumi Asano¹, Yasushi Saeki¹ (1. The Institute of Medical Science, The University of Tokyo)

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10:00 AM - 10:15 AM JST(1:00 AM - 1:15 AM UTC)

[WS09-05]Development of a Large-Scale Measurement Platform for Understanding Protein Lifetimes

*Eisuke Kanao^1,2 (1. Department of pharmaceutical sciences, Kyoto university, 2. NIBIOHN)

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