Session Details
[S12]Understanding the formation of multicellular organisms from cell-cell adhesion and extracellular matrix[E]
Fri. Jul 18, 2025 9:00 AM - 11:00 AM JST
Fri. Jul 18, 2025 12:00 AM - 2:00 AM UTC
Fri. Jul 18, 2025 12:00 AM - 2:00 AM UTC
Room E(9F Conference Room902)
Chairpersons:Yukako Oda(Kyoto Univ.), Tetsuhisa Otani(TMU)
Co-hosted by:Grant-in-Aid for Transformative Research Areas (A), Multicellular Autonomy
Cell adhesion plays pivotal roles in the epithelial barrier, cell migration, or tissue morphogenesis and is critical for the development and homeostasis of multicellular organisms. Increasing evidence suggests that mechanical forces and cell adhesion are intimately coupled with each other, and how the adhesion structures crosstalk with mechanical force is an exciting avenue of research. This symposium will cover cutting-edge research from diverse systems that are starting to uncover the crucial roles of the interplay between cell adhesion and mechanical force in multicellular organisms.
Cell adhesion plays pivotal roles in the epithelial barrier, cell migration, or tissue morphogenesis and is critical for the development and homeostasis of multicellular organisms. Increasing evidence suggests that mechanical forces and cell adhesion are intimately coupled with each other, and how the adhesion structures crosstalk with mechanical force is an exciting avenue of research. This symposium will cover cutting-edge research from diverse systems that are starting to uncover the crucial roles of the interplay between cell adhesion and mechanical force in multicellular organisms.
[S12-01]Molecular mechanisms involved in the rapid formation of de novo tight junctions
*Yuma Cho1, Akari Taniguchi1, Akiharu Kubo2, Junichi Ikenouchi1 (1. Faculty of Medical Sciences, Kyushu University, 2. Graduate School of Medicine, Kobe University)
[S12-02]Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis
*Tetsuhisa Otani1 (1. Tokyo Metropolitan Univ. Department of Biological Sciences)
[S12-03]Adhesion–Contraction Coupling in Heterotypic Cell Interactions Drives Mosaic Patterning of Sensory Epithelia
*Hideru Togashi1 (1. Kobe Univ. Biosignal Research Center)
[S12-04]Dynamic separation of cell-cell contacts induces RhoA and Myosin activity to drive zippering and neural tube closure in a simple chordate
*Hidehiko Hashimoto1, Takeo Horie1, Edwin Munro2 (1. The University of Osaka, 2. University of Chicago)
[S12-05]Mechano-chemical signaling induced by microtubules in directed cell migration
*Yukako Nishimura1, Tatsuki Kondo1, Ryota Orii2, Taketoshi Kambara3, Kaori Kuribayashi-Shigetomi4, Yasushi Okada3,5,6, Hirokazu Tanimoto2, Fumio Motegi1 (1. Hokkaido Univ., Inst. Gen. Med., 2. Yokohama City Univ., 3. RIKEN, BDR, 4. Hokkaido Univ., Inst. Adv. Grad. Edu., 5. Univ. of Tokyo, Dept. Phys., 6. Univ. of Tokyo, Dept. Cell Biol.)
[S12-06]Body shape control by ECM folding and unfolding in Drosophila
*Reiko Tajiri1 (1. Chiba University, Graduate School of Science)