講演情報
[P148]カンゾウおよびキキョウの根抽出物による免疫賦活作用の解析
*リー シマン1、 小林 夕希子2、川手 菜々子1、伊藤 英晃1、奥田 傑1、岡本 研1、川上 浩1、堤 研太1、米山 拓2、楊 金緯2、立﨑 仁2、永田 宏次1 (1. 東京大学大学院農学生命科学研究科応用生命化学専攻 、2. 常磐植物化学研究所)
キーワード：
インターロイキン12（IL-12）、インターフェロンγ（IFN-γ）、マクロファージの貪食作用、免疫賦活作用、THP-1
[Purpose] Glycyrrhiza glabra and Platycodon grandiflorus, recognized as traditional medicinal herbs, have been incorporated into cuisines and local ointments for decades. However, limited research has been conducted on their immunostimulatory properties and underlying mechanisms.
[Methods] In this study, we investigated the ability of root extracts from G. glabra and P. grandiflorus to stimulate cytokine production, specifically interleukin-12 (IL-12), interferon-γ (IFN-γ) and interferon-α (IFN-α), as well as their effects on macrophage phagocytic activity using the THP-1 cell line.
[Result] We found that the root extracts from G. glabra significantly enhanced the production of IL-12 and IFN-γ and promoted macrophage phagocytosis, surpassing the effects of the positive control, Lactococcus lactis strain Plasma (LC-Plasma). However, neither root extracts induced higher levels of IFN-α compared to LC-Plasma. These findings suggest that both G. glabra and P. grandiflorus exhibit immunostimulatory effects and hold promise as potential therapeutic agents for immune-related disorders. Further studies are warranted to elucidate the mechanisms underlying these effects.
[Methods] In this study, we investigated the ability of root extracts from G. glabra and P. grandiflorus to stimulate cytokine production, specifically interleukin-12 (IL-12), interferon-γ (IFN-γ) and interferon-α (IFN-α), as well as their effects on macrophage phagocytic activity using the THP-1 cell line.
[Result] We found that the root extracts from G. glabra significantly enhanced the production of IL-12 and IFN-γ and promoted macrophage phagocytosis, surpassing the effects of the positive control, Lactococcus lactis strain Plasma (LC-Plasma). However, neither root extracts induced higher levels of IFN-α compared to LC-Plasma. These findings suggest that both G. glabra and P. grandiflorus exhibit immunostimulatory effects and hold promise as potential therapeutic agents for immune-related disorders. Further studies are warranted to elucidate the mechanisms underlying these effects.
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